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Dr Duke's list of Chemicals and their Biological Activities in: Piper methysticum G. FORSTER (Piperaceae) -- Kava-Kava

Identifier

019180

Type of Spiritual Experience

Background

A description of the experience

Chemicals and their Biological Activities in: Piper methysticum G. FORSTER (Piperaceae) -- Kava-Kava


Chemicals

11,12-DIMETHOXYDIHYDROKAWAIN Plant: DUKE1992A

No activity reported.

11-HYDROXY-12-METHOXYDIHYDROKAWAIN Plant: DUKE1992A

No activity reported.

11-METHOXYNORYANGONIN Plant: DUKE1992A

No activity reported.

11-METHOXYYANGONIN Plant: DUKE1992A

No activity reported.

2',4'-DIMETHYLCHALCONARINGENIN Plant: DUKE1992A

No activity reported.

3,4-(METHYLENE-DIOXY)CINNAMYLIDENACETOL Plant: DUKE1992A

No activity reported.

5,6,7,8-TETRAHYDROYANGONIN Plant: DUKE1992A

No activity reported.

5-DIHYDROYANGONIN Plant: DUKE1992A

No activity reported.

BENZOIC-ACID Plant: DUKE1992A

Allergenic MAR ; Anesthetic DUKE1992B ; Antibacterial 33-1,250 ppm JNP49:5750 MBC=800 ug/ml JNP49:5750 ; Antiotitic MAR ; Antipyretic DUKE1992B ; Antisalmonella MIC=800 ug/ml JNP49:5750 ; Antiseptic 800 ug/ml; Antiyeast MFC=1,600 ug/ml JAF50:3992 ; Choleretic JBH ; Expectorant DUKE1992B ; FLavor FEMA 250 ARC ; Fungicide MFC=1,600 ug/ml; Insectifuge 382 ; Pesticide DUKE1992B ; Phytoalexin JBH ; Tyrosinase-Inhibitor ID50=640 uM JAF51:2837 ID50=710 uM JAF50:1400 ; Uricosuric DUKE1992B ; Vulnerary JE26:82

CINNAMIC-ACID Plant: DUKE1992A

Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) SKN43:99 ; Allergenic M&R317 ; Anesthetic DUKE1992B ; Antibacterial MAR ; Antiinflammatory PMP25:55 ; Antimutagenic EMP6:235 ; Antispasmodic JBH ; Cancer-Preventive 525 ; Choleretic DUKE1992B ; Dermatitigenic JBH ; FLavor FEMA 4-40 ARC ; Fungicide DUKE1992B ; Herbicide DUKE1992B ; Laxative DUKE1992B ; Lipoxygenase-Inhibitor RWG141 ; Pesticide DUKE1992B ; Tyrosinase-Inhibitor ID50=700 uM; Vermifuge JE26:81

CINNAMYLIDENACETOL Plant: DUKE1992A

No activity reported.

DEMETHOXYYANGONIN Plant: DUKE1992A

No activity reported.

DESMETHOXYYANGONIN Plant: DUKE1992A

No activity reported.

DIHYDROKAWAIN Plant: DUKE1992A

Analgesic 150 mg/kg ipr mus; Anesthetic 0.25%; Anticonvulsant PH2 ; Antidote (Strychnine) SHT67 ; Antiinflammatory DUKE1992B ; Antinociceptive; Antipyretic PJB1(1):173 ; Antispasmodic SHT67 ; Endoanesthetic 5-20 mg/kg ORNM:259.1996 ; Fungistat LAF ; MAO-B-Inhibitor PH2 ; Myorelaxant 90 mg/kg; Neuroprotective SHT67 ; Sedative LAF

DIHYDROKAWAIN-5-OL Plant: DUKE1992A

No activity reported.

DIHYDROMETHYSTICIN Plant: DUKE1992A

Analgesic LAF ; Anesthetic 0.25%; Anticonvulsant ED50 140 mg/kg orl mus; Antidote (Strychnine) STH67 ; Antiepileptic 800 mg/man QRNM:259.1996 ; Antiinflammatory DUKE1992B ; Antiischemic 10-30 mg/kg ivn mus; Antinociceptive; Antipyretic DUKE1992B ; Antispasmodic JBH ; CNS-Depressant LRN-MAY87 ; Dermatitigenic DUKE1992B ; Endoanesthetic 5-20 mg/kg QRNM:259:1996 ; MAO-B-Inhibitor PH2 ; Myorelaxant 60 mg/kg IC50 20 mg/kg ivn mus HH2 ; Neuroprotective 10-30 mg/kg ivn mus; Sedative 60 mg/kg ipr

FLAVOKAWAIN-C Plant: DUKE1992A

No activity reported.

FLAVOKAWIN-A Plant: DUKE1992A

No activity reported.

FLAVOKAWIN-B Plant: DUKE1992A

No activity reported.

KAWAIN Plant: DUKE1992A

Analgesic 300 mg/kg ipr mus; Anesthetic =cocaine 0.25%; Antiaggregant IC50=71-115 uM/l PM63:27 ; Antiarachidonate PM63:27 ; Anticonvulsant QRNM:259.1996 ; Antidote (Strychnine) (3 mg/kg) IC50=98 mg/kg QRNM:259.1996 ; Antiedemic JBH ; Antifibrillary 20 mg/kg QRNM:259.1996 ; Antiinflammatory JBH ; Antimycotic JBH ; Antinociceptive HH2 ; Antiprostaglandin JAF50:701 ; Antipyretic DUKE1992B ; Antiseptic DUKE1992B ; Antispasmodic JBH ; Antithrombotic; Antithromboxane IC50=71-115 uM/l PM63:27 ; Anxiolytic PH2 ; CNS-Depressant LRN-MAY87 ; Cyclooxygenase-Inhibitor PM63:27 ; Endoanesthetic 5-20 mg/kg QRNM:259.1996 ; Fungicide JBH ; MAO-B-Inhibitor PH2 ; Myorelaxant 60 mg/kg ipr IC50 20 mg/kg ivn mus HH2 ; Neurotoxic RJH ; Pesticide DUKE1992B ; Sedative 60 mg/kg ipr; Tranquilizer HG24:37

KAWAINIC-ACID Plant: DUKE1992A

No activity reported.

METHYSTICIN Plant: DUKE1992A

Analgesic 360 mg/kg ipr mus HH2 ; Anesthetic 0.25%; Anticonvulsant RJH ; Antidote (Strychnine) (Strychnine 3 mg/kg) IC=31 mg/kg QRNM:259.1996 ; Antifibrillary 20 mg/kg QRNM:259.1996 ; Antiinflammatory CRC ; Antiischemic 10-30 mg/kg ivn mus; Antinociceptive PH2 ; Antipyretic CRC ; Antispasmodic JBH ; CNS-Depressant LRN-MAY87 ; Endoanesthetic 5-20 mg/kg QRNM:259.1996 ; MAO-B-Inhibitor PH2 ; Myorelaxant 45 mg/kg; Neuroprotective 10-30 mg/kg ivn mus; Neurotoxic RJH ; Psychoactive RJH ; Sedative 45 mg/kg ipr HH2

PIPERMETHYSTINE Plant: DUKE1992A

No activity reported.

YANGONIN Plant: DUKE1992A

Amebicide DUKE1992B ; Anesthetic DUKE1992B ; Antibacterial DUKE1992B ; Antiinflammatory DUKE1992B ; Antipyretic DUKE1992B ; Antispasmodic JBH ; CNS-Depressant LRN-MAY87 ; MAO-B-Inhibitor PH2 ; Myorelaxant 45 mg/kg ipr IC50 5 mg/kg ivn mus HH2 ; Pesticide DUKE1992B ; Sedative 45 mg/kg ipr HH2

The source of the experience

Dr Dukes plant database

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Suppressions

Kava

Commonsteps

References

382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

ARC: Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Note: Most ARC numerical data were in mg/dl. I know of no other plant where zinc is more prevalent than other minerals and protein. These data should be viewed as suspect.

CRC: CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP6:235: Economic & Medicinal Plant Research, 6: 235.

HG24:37: HerbalGram No. 24, page 37.

HH2: Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.

JAF50:1400: Jim Duke's personal files

JAF50:3992: Jim Duke's personal files

JAF50:701: Jim Duke's personal files

JAF51:2837: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JE26:81: Jim Duke's personal files

JE26:82: Jim Duke's personal files

JNP49:5750: Jim Duke's personal files

LAF: Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

LRN-MAY87: Jim Duke's personal files

M&R317: Jim Duke's personal files

MAR: Martindale's 28th

ORNM:259.1996: Jim Duke's personal files

PH2: Jim Duke's personal files

PJB1(1):173: Jim Duke's personal files

PM63:27: Jim Duke's personal files

PMP25:55: Jim Duke's personal files

QRNM:259.1996: Jim Duke's personal files

QRNM:259:1996: Jim Duke's personal files

RJH: R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.

RWG141: Jim Duke's personal files

SHT67: Jim Duke's personal files

SKN43:99: Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.

STH67: Jim Duke's personal files

ppm = parts per million
tr = trace