Observations placeholder

Copper imbalance and Wilson's disease

Identifier

006910

Type of Spiritual Experience

Hallucination

Number of hallucinations: 4

Background

Penicillamine is a pharmaceutical of the chelator class.   It is sold under the trade names of Cuprimine and Depen. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.

A description of the experience

J Neurol. 1993 Dec;241(2):101-7.  Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentration.  Hartard C, Weisner B, Dieu C, Kunze K.

The clinical courses, cerebrospinal fluid (CSF) and serum copper concentrations and urinary copper excretions under different schemes of drug treatment in four patients with cerebral manifestations of Wilson's disease were monitored over 6-11 years.

CSF copper concentration measurements were performed from the beginning of therapy onwards in three patients and from 16 months after initial treatment onwards in the fourth.

CSF copper levels decreased slowly over the years in parallel with clinical improvements, and increased in one patient who interrupted therapy for 2 years.

These findings confirm our hypothesis that the concentration of copper in the CSF is a valuable quantitative parameter reflecting the normalization of copper in the brain.

Copper measurements during phases of initial neurological deterioration in two patients receiving D-penicillamine, and in one patient receiving D-penicillamine and zinc sulphate, revealed decreased free serum copper and CSF copper levels.

PMID:8138824

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Copper imbalance

Suppressions

Chelation agents
Inherited genes
Zinc

Commonsteps

References