Type of Spiritual Experience
A description of the experience
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. It is marketed as a stand-alone drug or for use in combination with metformin or with glimepiride. First released in 1999, annual sales peaked at approximately $2.5-billion in 2006; however, following a meta-analysis published in the New England Journal of Medicine in 2007 that linked the drug's use to an increased risk of heart attack, sales plummeted to just $9.5-million in 2012. The drug's patent expired in 2012.
Adverse effects alleged to be caused by rosiglitazone were the subject of over 13,000 lawsuits against GSK; as of July 2010, GSK had agreed to settlements on more than 11,500 of these suits.
Most common Avandia side effects from eHealthme
- Heart attack - (52,845 reports)
- Cardiac failure congestive - (32,825 reports)
- Stroke - (22,461 reports)
- Coronary heart disease - (11,880 reports)
- Cardiac disorder - (8,425 reports)
- Death - (7,386 reports)
- Injury - (4,379 reports)
- Chest pain - (3,951 reports)
- Acute myocardial infarction - (3,837 reports)
- Myocardial ischaemia - (3,754 reports)
Some reviewers recommended rosiglitazone be taken off the market, but an FDA panel disagreed, and it remains available in the U.S. From November 2011 until November 2013, the federal government did not allow Avandia to be sold without a prescription from a certified doctor; moreover, patients were required to be informed of the risks associated with its use, and the drug had to be purchased by mail order through specified pharmacies. In November 2013, the FDA lifted its earlier restrictions on rosiglitazone after reviewing the results of the 2009 RECORD clinical trial (a six-year, open label randomized control trial), which failed to show heart infarct risks associated with the drug [sic].
In Europe, the European Medicines Agency (EMA) recommended in September 2010 that the drug be suspended from the European market because the benefits of rosiglitazone no longer outweighed the risks. It was withdrawn from the market in the UK and India in 2010, and in New Zealand and South Africa in 2011.
On Jan, 24, 2017 140,918 people reported to have side effects when taking Avandia.
Among them, 71 people (0.05%) have Hallucination
On Jan, 19, 2017 140,918 people reported to have side effects when taking Avandia.
Among them, 38 people (0.03%) have Hallucination, Auditory
On Jan, 21, 2017 140,918 people reported to have side effects when taking Avandia.
Among them, 2 people (0.0%) have Hallucination, Tactile