A placebo-controlled study of the effects of L-tryptophan in patients with premenstrual dysphoria
Type of Spiritual Experience
Tryptophan is better obtained via food - see the tryptophan link
A description of the experience
Adv Exp Med Biol. 1999;467:85-8.
A placebo-controlled study of the effects of L-tryptophan in patients with premenstrual dysphoria.
Steinberg S1, Annable L, Young SN, Liyanage N.
- 1Department of Psychiatry, McGill University, Montréal, Québec, Canada.
In a randomized controlled clinical trial, 37 patients with premenstrual dysphoric disorder were treated with L-tryptophan 6 g per day and 34 were given placebo.
The treatments were given under double-blind conditions for 17 days, from the time of ovulation to the third day of menstruation, during three consecutive cycles. Visual Analog Mood Scales revealed a significant (p = 0.004) therapeutic effect of L-tryptophan relative to placebo for the cluster of mood symptoms comprising the items dysphoria, mood swings, tension and irritability. These results suggest that increasing serotonin synthesis during the late luteal phase of the menstrual cycle is therapeutic in patients with premenstrual dysphoric disorder.
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps
Fury, overwhelming rage and anger
Reproductive system disease