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Collagenase clotsridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis., which is manufactured and marketed as Xiaflex in the US and  as Xiapex in Europe.

Side effects

The most common side effects include lymphadenopathy (swollen lymph nodes), itching, pain, oedema, and bleeding (for example in the form of bruises or ecchymoses). Allergic reactions are seen in less than 1% of patients.

On Feb, 18, 2016: 362 people reported to have side effects when taking Xiaflex. Among them, 1 people (0.28%) has Hallucination.

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On Feb, 18, 2016: 362 people reported to have side effects when taking Xiaflex. Among them, 1 people (0.28%) has Death.

Time on Xiaflex when people have Death  :

Gender of people who have Death when taking Xiaflex  :

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Top conditions involved for these people  :

1. Dupuytren's contracture (1 people, 100.00%)