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Effect of Carthamus tinctorius (Safflower) on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits
Identifier
020849
Type of Spiritual Experience
Background
A description of the experience
Pak J Pharm Sci. 2014 Mar;27(2):377-80.
Effect of Carthamus tinctorius (Safflower) on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits.
Qazi N1, Khan RA2, Rizwani GH3, Feroz Z4.
- 1Department of Pharmacology, Liaqat University of Medical and Health Sciences, Jamshoro, Pakistan.
- 2Department of Basic Medical Sciences, College of Medicine-Jeddah, King Saud Bin Abdulaziz University for Health Sciences, Kingdom of Saudi Arabia.
- 3Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
- 4College of Science of Health Professions, Department of Basic Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Abstract
Diabetes mellitus is a major threat to present and future generations. The role of herbal medication has emerged as a safe alternative to currently available medication due to its decreased potential to produce side effects, hence effect of Carthamus tinctorius was observed on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits.
Thirty five healthy male rabbits were divided into 5 groups with 7 rabbits in each (Normal control, diabetic control, diabetic treated with glibenclamide, diabetic treated with Carthamus tinctorius extract at doses of 200 and 300mg/kg of body weight).
Drug and extract were given orally for 30 days and the values for blood glucose levels were observed after 15(th) and 30(th) day of treatment by using standard reagent kits provided by Human Germany. While insulin levels were checked at the end of the study by using Architect i1000 by Abbott Diagnostics USA.
Animals were also observed for any gross toxicity during the study.
Results revealed that Carthamus tinctorius has significant hypoglycemic effect at 200mg/kg and 300mg/kg doses as compared to diabetic control group. Insulin levels were significantly increased in Glibenclamide treated as well as Carthamus tinctorius treated groups as compared to diabetic control.
PMID: 24577929