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Tretinoin (etymology and pronunciation) is retinoic acid in pharmaceutical form. One of several retinoids, it is the carboxylic acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a first generation topical retinoid commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel (brand names Aberela, Airol, A-Ret, Atralin, Avita, Retacnyl, Refissa, Renova, Retin-A, Retino-A, ReTrieve, or Stieva-A). The most common strengths are 0.025%, 0.05% and 0.1%. It is also used to treat acute promyelocytic leukemia (APL),the brand name Vesanoid.

Acute promyelocytic leukemia (APML, APL) is the M3 subtype of acute myelogenous leukemia (AML), a cancer of the white blood cells. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes.

Topical tretinoin should be avoided during pregnancy because its use has been linked to birth defects in several case reports.

On Feb, 18, 2016: 954 people reported to have side effects when taking Vesanoid. Among them, 2 people (0.10%) has Hallucination.

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On Feb, 18, 2016: 954 people reported to have side effects when taking Vesanoid. Among them, 14 people (1.47%) have Death.

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