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Observations placeholder

Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial

Identifier

019897

Type of Spiritual Experience

Background

A description of the experience

Rhinology. 2009 Mar;47(1):51-8.

Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial.

Bachert C1, Schapowal A, Funk P, Kieser M.

  • 1University of Ghent, ENT Department, Ghent, Belgium. claus.bachert@ugent.be

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of the herbal drug preparation from the roots of Pelargonium sidoides (EPs 7630) compared to placebo.

DESIGN:

Double-blind, randomized, placebo-controlled, parallel-group, multicenter trial with a group-sequential adaptive design.

SUBJECTS:

Patients with sinonasal symptoms of at least 7 days duration, and radiographically and clinically confirmed acute rhinosinusitis of presumably bacterial origin with a Sinusitis Severity Score (SSS) of at least 12 out of 24 points at inclusion.

INTERVENTIONS:

EPs 7630, a herbal drug preparation from the roots of Pelargonium sidoides (1: 8-10; extraction solvent: ethanol 11% (w/w)), or matching placebo at a dose of 60 drops three times daily for maximum 22 days.

MAIN OUTCOME MEASURES:

Change in the SSS after 7 days.

RESULTS:

103 patients were recruited until the planned interim analysis. The mean decrease in the SSS was 5.5 points in the EPs 7630 group compared to 2.5 points in the placebo group, a difference of 3.0 points (95% confidence interval 2.0 to 3.9, p < 0.00001). This result was confirmed by all secondary parameters indicating a more favourable course of the disease and a faster recovery in the EPs 7630 group. According to the pre-specified decision rule, the study was stopped after obtaining proof of efficacy for EPs 7630.

CONCLUSIONS:

EPs 7630 was well tolerated and superior in efficacy compared to placebo in the treatment of acute rhinosinusitis of presumably bacterial origin.

PMID:

19382496

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Nose diseases

Suppressions

Pelargonium

Commonsteps

References