Type of Spiritual Experience
A description of the experience
Labetalol, sold under the trade names Normodyne among others, is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure. It can be given intravenously in severe hypertensive situations, or by mouth for long term hypertension management. Its dose and use is limited by its main side effect—postural hypotension, where there is a substantial drop in blood pressure when standing upLabetalol's dual alpha- and beta- blockade has different physiological effects in short and long term situations. In short term, acute situations, labetalol decreases blood pressure by decreasing systemic vascular resistance with little effect on stroke volume, heart rate and cardiac output During long term use, labetalol can reduce heart rate during exercise while maintaining cardiac output by an increase in stroke volume
- Neurologic: Headache (2%), Dizziness (11%)
- Gastrointestinal: Nausea (6%), Dyspepsia (3%)
- Cholinergic: Nasal congestion (3%), Ejaculation failure (2%)
- Respiratory: Dyspnea (2%)
- Other: Fatigue (5%), Vertigo (2%), Orthostatic hypotension
Low blood pressure with standing is more severe and more common with IV formulation (58% vs 1%) and is often the reason larger doses of the oral formulation cannot be used.
- Muscle cramps
- Dry eyes
- Heart block
- Drug eruption similar to lichen planus
- Hypersensitivity - which may result in a lethal respiratory distress
On Jan, 28, 2016: 858 people reported to have side effects when taking Trandate. Among them, 2 people (0.23%) have Hallucination.
On Feb, 13, 2016: 858 people reported to have side effects when taking Trandate. Among them, 14 people (1.63%) have Death.
Time on Trandate when people have Death :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years|