Observations placeholder
The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms
Identifier
019350
Type of Spiritual Experience
Background
Lepidium is a genus of plants in the mustard/cabbage family, Brassicaceae. The genus is widely distributed in the Americas, Africa, Asia, Europe, and Australia. It includes familiar species such as garden cress, maca, and dittander. General common names include peppercress, peppergrass, and pepperwort. Some species form tumbleweeds
A description of the experience
Bioorg Med Chem Lett. 2002 Sep 2;12(17):2435-7.
The activity of p-methoxybenzylisothiocyanate against Neisseria gonorrhoeae, Haemophilus ducreyi, and other microorganisms.
Swart H1, Van Dyk S, Malan SF.
- 1Pharmaceutical Chemistry, Potchefstroomse Universiteit vir Christelike Hoër Onderwys, Potchefstroom, South Africa. fchhs@puknet.puk.ac.za
Abstract
p-Methoxybenzylisothiocyanate was isolated from Lepidium bonariense and found to be responsible for the plants antimicrobial and STD activity.
MIC determinations were conducted for p-methoxybenzylisothiocyanate on Haemophilus ducreyi, Neisseria gonorrheae, Candida albicans, Bacillus subtilus, Micrococcus luteus, Staphylococcus aureus, Enterobacter sp., Escherichia coli, Klebsiella pneumoniae, and Psuedomanas aeruginosa.
An in vitro cellular toxicity assay showed that at 100 microM (17,9 microg/mL) p-methoxybenzylisothiocyanate is not toxic to living cells.
PMID: 12161151