Vitamin D status in patients with chronic plaque psoriasis and rheumatoid arthritis
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Br J Dermatol. 2012 Mar;166(3):505-10. doi: 10.1111/j.1365-2133.2011.10699.x. Epub 2012 Feb 6. Vitamin D status in patients with chronic plaque psoriasis. Gisondi P1, Rossini M, Di Cesare A, Idolazzi L, Farina S, Beltrami G, Peris K, Girolomoni G. Department of Medicine, Section of Dermatology and Venereology, Section of Rheumatology III Division of Geriatrics, University of Verona, Verona, Italy. email@example.com
BACKGROUND: Vitamin D could have important immunomodulatory effects in psoriasis.
OBJECTIVES: To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.
METHODS: A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected.
RESULTS: The prevalence of vitamin D deficiency [25(OH)D levels <20ngmL(-1) ] was
- 57·8% in patients with psoriais
- 37·5% in patients with RA and
- 29·7% in healthy controls (P<0·001).
In winter, the prevalence of vitamin D deficiency rose to
- 80·9% in patients with psoriasis,
- 41·3% in those with RA and to
- 30·3% in healthy controls (P<0·001).
Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling.
A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established.
CONCLUSIONS: Vitamin D deficiency may be common in patients with psoriasis, especially in winter.
© 2011 The Authors. BJD © 2011 British Association of Dermatologists.