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Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil) is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly potent typical antipsychotic, 10–20 times more potent than chlorpromazine. It is also used to treat migraine headaches.   Intravenous administration can be used to treat status migrainosus.

Side effects

Nervous system side effects have been associated with the use of prochlorperazine. Extrapyramidal side effects such as acute dystonic reactions, pseudoparkinsonism, or akathisia can affect 2% of patients at low doses, whereas higher doses may affect as many as 40% of patients.

Prochlorperazine can also cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include: high fever, stiff muscles, confusion, irregular pulse or blood pressure, fast heart rate (tachycardia), sweating, irregular heart rhythms (arrhythmias). VA and FDA research shows injection site reaction.

On Jan, 29, 2016: 1,160 people reported to have side effects when taking Prochlorperazine. Among them, 32 people (2.76%) have Death.

Time on Prochlorperazine when people have Death  :

 On Jan, 29, 2016: 576 people reported to have side effects when taking Prochlorperazine edisylate. Among them, 11 people (1.91%) have Death.

Time on Prochlorperazine edisylate when people have Death  :

On Jan, 29, 2016: 1,550 people reported to have side effects when taking Prochlorperazine maleate. Among them, 52 people (3.35%) have Death.