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Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. The chemical structure of piperacillin and other ureidopenicillins incorporates a polar side chain that enhances penetration into Gram-(-) bacteria and reduces susceptibility to cleavage by Gram-(-) beta lactamase enzymes. These properties confer activity against the important hospital pathogen Pseudomonas aeruginosa. Thus piperacillin is sometimes referred to as an "anti-pseudomonal penicillin".

When used alone, piperacillin lacks strong activity against the Gram positive pathogen Staphylococcus aureus, as the beta-lactam ring is broken by the bacteria's beta-lactamase

Adverse effects

The most common adverse effects associated with piperacillin-tazobactam are diarrhea, constipation, nausea, headache and insomnia. Less commonly, severe adverse effects may include anaphylaxis, Stevens-Johnson syndrome, and Clostridium difficile associated diarrhea

On Jan, 29, 2016: 2,387 people reported to have side effects when taking Piperacillin. Among them, 9 people (0.38%) have Hallucination.

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On Jan, 20, 2016: 2,387 people reported to have side effects when taking Piperacillin. Among them, 52 people (2.18%) have Death.

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Top conditions involved for these people  :

1. Hypertension (8 people, 15.38%)
2. Pain (8 people, 15.38%)