Observations placeholder
Niridazole / Ambilhar
Identifier
006106
Type of Spiritual Experience
Background
Wikipedia " Niridazole is a schistosomicide. It is used to treat schistosomiasis, the helmintic disease caused by certain flatworms (trematodes) from the genus Schistosoma (formerly Bilharzia). It is also known by its trade name Ambilhar. It is usually is given as tablets. Niridazole has central nervous system toxicity and can cause dangerous side effects, such as hallucinations. Also, it may cause allergic reactions in sensitive people."
A description of the experience
Southeast Asian J Trop Med Public Health. 1976 Jun;7(2):348-50. Ambilhar in the treatment of Schistosoma japonicum infection and as an egg suppressant for mass treatment. Blas BL.
Ambilhar or niridazole at a dose of 25 mg per kg body weight for 7 days was found ineffective against Sl japonicum infection.
Longer period of treatment for 10 to 14 days gave impressive stool negative conversion and egg reduction rates but with moderately severe reactions, the most alarming of which was hallucination.
To minimize toxicity, the daily dose was reduced but given for a longer duration so that the total amount of the drug given per kilogram body weight was approximately the same as the 25 mg pre kg per day for 10 to 14 days. Of the two treatment schedules tried, the 15 mg per kg per day for 24 days was found relatively effective.
Although the drug with this treatment regimen was well tolerated, a drop-out of 50.8% was observed.
Ambilhar was therefore tried as an egg suppressant.
With a 10-day treatment, all patients were again positive after 6 months. Egg reduction rates during the 6 months stool follow-up ranged from 69.8 to 93.5%. Further trials using this dose to be repeated every 3 to 6 months is contemplated.
PMID: 1025735