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This book, which covers Visions and hallucinations, explains what causes them and summarises how many hallucinations have been caused by each event or activity. It also provides specific help with questions people have asked us, such as ‘Is my medication giving me hallucinations?’.

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Observations placeholder

Maprotiline Hydrochloride



Type of Spiritual Experience


Number of hallucinations: 5


A description of the experience

Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a medication that belongs to tetracyclic antidepressants (TeCA), a specific group of antidepressants.

Side effects

The side-effect profile is comparable to other tri-/tetracyclic antidepressants and many of the following are due to anticholinergic (which are less prominent than those of most tricyclic antidepressants) and antihistaminergic effects Most often seen are:

  • Dizziness
  • Drowsiness
  • Somnolence
  • fatigue
  • Dry mouth (and complications of long-term uncontrolled dry mouth such as dental caries)
  • Constipation
  • Vertigo
  • Nausea (rare, incidence of ~2%) and vomiting
  • Increased appetite and weight gain
  • Orthostatic hypotension, hypertension, sinus tachycardia, heart-block, arrhythmias and other cardiac effects
  • Sexual dysfunction in men: impotence, priapism, delayed ejaculation, anejaculation, decreased libido
  • Sexual dysfunction in women: decreased libido, vaginal dryness, painful sexual intercourse, anorgasmia
  • Allergic skin reactions such as rash or urticaria (more often than with other antidepressants). Rarely, severe skin reactions such as erythema multiforme can occur.
  • Photosensitivity
  • Agitation, confusion
  • Induction of hypomania or mania in patients suffering from underlying bipolar affective disorder
  • Psychotic symptoms
  • Tremor
  • Extrapyramidal symptoms
  • Headache
  • Seizures (at high doses)
  • Rare haematological complications: leukopenia and agranulocytosis (dangerous fall in white blood cells)
  • Fever
  • Urinary retention

Maprotiline causes a strong initial sedation (first 2 to 3 weeks of therapy) and is therefore indicated to treat agitated patients or those with suicidal risks. It causes anticholinergic side effects (dry mouth, constipation, confusion, tachycardia) with a lower incidence than amitriptyline. Originally, the manufacturer claimed that maprotiline is better tolerated than other tri-/tetracyclic drugs. However, seizures, leukopenia and skin reactions occur more often with maprotiline than with comparable drugs like amitriptyline.

On Jan, 6, 2016: 189 people reported to have side effects when taking Maprotiline hydrochloride. Among them, 5 people (2.65%) have Hallucination.


On Jan, 6, 2016: 189 people reported to have side effects when taking Maprotiline hydrochloride. Among them, 1 people (0.53%) has Death.

Time on Maprotiline hydrochloride when people have Death  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Death 0.00% 100.00% 0.00% 0.00% 0.00% 0.00% 0.00%

Gender of people who have Death when taking Maprotiline hydrochloride  :

  Female Male
Death 100.00% 0.00%




The source of the experience


Concepts, symbols and science items



Science Items

Activities and commonsteps