Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease
Type of Spiritual Experience
A description of the experience
Phytother Res. 1999 Feb;13(1):31-6.
Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.
Hussein G1, Miyashiro H, Nakamura N, Hattori M, Kawahata T, Otake T, Kakiuchi N, Shimotohno K.
- 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication.
Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method.
Of the tested extracts, the methanol extracts of
- Acacia nilotica (bark and pods),
- Euphorbia granulata (leaves),
- Maytenus senegalensis (stem-bark)
and aqueous extracts of
- A. nilotica (pods) and
- M. senegalensis (stem-bark)
showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.