Phytother Res. 1999 Feb;13(1):31-6.

Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.

Hussein G1, Miyashiro H, Nakamura N, Hattori M, Kawahata T, Otake T, Kakiuchi N, Shimotohno K.

• 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

Abstract

Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication.

Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method.

Of the tested extracts, the methanol extracts of

• Acacia nilotica (bark and pods),
• Euphorbia granulata (leaves),
• Maytenus senegalensis (stem-bark)

and aqueous extracts of

• A. nilotica (pods) and
• M. senegalensis (stem-bark)

showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.

PMID:

10189947