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Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease

Identifier

019177

Type of Spiritual Experience

Background

A description of the experience

Phytother Res. 1999 Feb;13(1):31-6.

Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.

Hussein G1, Miyashiro H, Nakamura N, Hattori M, Kawahata T, Otake T, Kakiuchi N, Shimotohno K.

  • 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

Abstract

Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication.

Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method.

Of the tested extracts, the methanol extracts of

  • Acacia nilotica (bark and pods),
  • Euphorbia granulata (leaves),
  • Maytenus senegalensis (stem-bark)

and aqueous extracts of

  • A. nilotica (pods) and
  • M. senegalensis (stem-bark)

showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.

PMID:

10189947

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

HIV

Suppressions

Babul
Maytenus senegalensis

Commonsteps

References