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Hypoglycemic activity evaluation and chemical study on hollyhock flowers

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017636

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Fitoterapia. 2015 Apr;102:7-14. doi: 10.1016/j.fitote.2015.02.001. Epub 2015 Feb 9.

Hypoglycemic activity evaluation and chemical study on hollyhock flowers.

Zhang Y1, Jin L2, Chen Q3, Wu Z2, Dong Y1, Han L3, Wang T4.

  • 1Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, PR China.
  • 2Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, PR China.
  • 3Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae (Tianjin University of Traditional Chinese Medicine), Ministry of Education, 312 Anshanxi Road, Nankai District, Tianjin 300193, PR China.
  • 4Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, PR China. Electronic address: wangtao@tjutcm.edu.cn.

Abstract

Hollyhock (Althaea rosea (Linn.) Cavan) belongs to Althaea genus, Malvaceae family, is a perennial garden plant distributed throughout the world in warm temperate and tropical regions, which was used as anti-diabetes ingredient in traditional Chinese medicine. In the process of our research, ethanolic extract of hollyhock flower (HFE) was found to decrease serum triglyceride and glucose levels significantly in KK-A(y) mice after oral administration for 8weeks. Meanwhile, gene expressions on AMPK, IRS2, PI3K, AKT and GLUT4 in liver were remarkably up-regulated. Three new dihydroflavonol glycosides, named as roseaflavanonolosides A (1), B (2), and C (3), together with two known ones were obtained from HFE. Their structures were elucidated by chemical and spectroscopic methods. Hepatic cell glucose uptake experiment was performed using 2-NBDG as a glucose uptake indicator. At the dosage of 20μg/mL for 1-5, the glucose uptake increasing level was nearly 30%-40% in HepG2 cells. We partly revealed the glucose metabolism regulation effect may relate to dihydroflavonols in hollyhock flower.

Copyright © 2015 Elsevier B.V. All rights reserved.

KEYWORDS:

Althaea rosea; Dihydroflavonol glycosides; Glucose and lipid regulation; Glucose uptake; HepG2 cells; Hollyhock flower

PMID:  25677352

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PubMed

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Diabetes
Diabetes treatments

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Marsh mallow

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