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Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

In general pharmaceuticals have a detrimental effect on all inflammatory problems, but this drug has a particularly poor record

On Oct, 22, 2017 29,903 people reported to have side effects when taking Accutane.
Among them, 7,224 people (24.16%) have Crohns disease

Time on Accutane when people have Crohns disease *:

• < 1 month: 5.61 %
• 1 - 6 months: 55.09 %
• 6 - 12 months: 16.48 %
• 1 - 2 years: 13.7 %
• 2 - 5 years: 7.09 %
• 5 - 10 years: 1.43 %
• 10+ years: 0.61 %

Gender of people who have Crohns disease when taking Accutane *:

• female: 44.98 %
• male: 55.02 %

Top other side effects for these people *:

• Inflammatory Bowel Disease (6,534 people, 90.45%)
• Depression (4,087 people, 56.58%)
• Ulcerative Colitis (3,789 people, 52.45%)
• Irritable Bowel Syndrome (2,596 people, 35.94%)
• Colitis (2,464 people, 34.11%)