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Green tea, mushrooms and breast cancer

Identifier

005387

Type of Spiritual Experience

Background

A description of the experience

 

Int J Oncol. 2007 Apr;30(4):963-9. Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. Thyagarajan A, Zhu J, Sliva D. Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA.

Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine.

In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells.

This effect was mediated by the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells.

Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers.

PMID: 17332936

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Breast cancer
Cancer

Suppressions

Mushrooms
Tea

Commonsteps

References