Gram-positive bacteria specific properties of silybin derived from Silybum marianum
Type of Spiritual Experience
A description of the experience
Arch Pharm Res. 2003 Aug;26(8):597-600.
Gram-positive bacteria specific properties of silybin derived from Silybum marianum.
Lee DG1, Kim HK, Park Y, Park SC, Woo ER, Jeong HG, Hahm KS.
- 1Research Center for Proteineous Materials, Chosun University, Korea.
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.