Effect of physostigmine on morphine-induced postoperative pain and somnolence
Type of Spiritual Experience
A description of the experience
Br J Anaesth. 1982 Apr;54(4):429-34.
Effect of physostigmine on morphine-induced postoperative pain and somnolence.
Weinstock M, Davidson JT, Rosin AJ, Schnieden H.
The effects of physostigmine 1 mg i.v. were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10 mg/60 kg i.v. in 10 patients recovering from surgery. Within 5-10 min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values. Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.