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Cardiovascular system

A 38-year-old man suffered an ischemic stroke after taking a dietary supplement containing synephrine daily for 1 week. The patient had no medical history or atherosclerotic risk factors and took no medications. Other possible causes of ischemic stroke proved to be unremarkable. 40

A 52-year old woman developed unremitting tachycardia after consuming a daily dose of C. aurantium extract 500 mg (synephrine 30 mg/day). She had been taking thyroxine 50 mcg/day for hypothyroidism for about 10 years. 41

Another case report documents a 55-year-old woman with an acute-lateral-wall myocardial infarction. The patient was taking a dietary supplement containing C. aurantium 300 mg for weight loss for 1 year. She had numerous risk factors for myocardial infarction. 4

A 28-year-old man suffered a massive myocardial infarction after abusing synephrine tablets (dose not provided). An overdose of synthetic synephrine in children caused nausea, vomiting, irritation, tachycardia, and a rapid increase in blood pressure. 10

There is also a case report on variant angina with bitter orange. 42

Muscular system

A 22-year-old man developed rhabdomyolysis after consuming a synephrine-containing weight-loss formula. While exercising, the patient developed fatigue, dehydration, and myalgias. 43