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Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum

Identifier

019002

Type of Spiritual Experience

Background

A description of the experience

Mem Inst Oswaldo Cruz. 2010 Mar;105(2):168-73.

Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum.

Monzote L1, García M, Montalvo AM, Scull R, Miranda M.

  • 1Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad de la Habana, Cuba. monzote@ipk.sld.cu

Abstract

Leishmaniasis is one of the most important parasitic infections, but current treatments are unsatisfactory due to their toxicity, cost and resistance. Therefore, the development of new antileishmanial compounds is imperative. Many people who live in endemic areas use plants as an alternative to treat the disease. In this paper, we characterised the essential oil from Piper auritum, evaluated its cytotoxicity and determined its antileishmanial activity. The chromatogram obtained by gas chromatography revealed 60 peaks and we found that safrole was the most abundant compound, composing 87% of the oil. The oil was active against the promastigotes of Leishmania major, Leishmania mexicana, Leishmania braziliensis and Leishmania donovani with a favourable selectivity index against peritoneal macrophages from BALB/c mice. The Piper-oil inhibited the growing of intracellular amastigotes of L. donovani with an IC50 value of 22.3 +/- 1.8 microg/mL. This study demonstrates the usefulness of the essential oils as a promising alternative to treat leishmaniasis.

PMID:

20428676

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Leishmaniasis

Suppressions

Essential oils
Hoja santa

Commonsteps

Aromatherapy

References