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Observations placeholder

Cadmium and rhubarb

Identifier

016838

Type of Spiritual Experience

Background

Rheum emodi, commonly known as Himalayan rhubarb, is a medicinal herb used in the Indian Ayurvedic system of medicine. It belongs to the family Polygonaceae. The plant is found in the sub-alpine and alpine Himalayas at an altitude of 4000 meters

Gentamicin is an aminoglycoside antibiotic composed of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. However, gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis, or Legionella pneumophila. Gentamicin is also ototoxic and nephrotoxic, with this toxicity remaining a major problem in clinical use

A description of the experience

J Ethnopharmacol. 2005 Jan 4;96(1-2):121-5.  Effect of Rheum emodi (Revand Hindi) on renal functions in rats.  Alam MM1, Javed K, Jafri MA.

The renal effects of water-soluble (W-S) and water-insoluble (W-INS) portions of the alcoholic extract of Revand Hindi (Rheum emodi) were investigated on cadmium chloride, mercuric chloride, potassium dichromate and gentamicin-induced nephrotoxicity in rats and normal rats by monitoring the levels of urea nitrogen and creatinine in serum.

The present investigations provide evidences that W-S fraction has nephroprotective effect on all the proximal tubule segments (S1, S2 and S3) possibly through antioxidant action of the tannins present in the fraction. W-INS also improved the renal function by protecting S2 segment of proximal tubule nephrotoxicity induced by metals viz cadmium chloride and mercuric chloride in rat models, however, this fraction has been found to enhance gentamicin nephrotoxicity.

PMID:  15588659

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References