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Asafoetida and the common cold

Identifier

006978

Type of Spiritual Experience

Background

A description of the experience

 

J Med Chem. 2008 Feb 28;51(4):842-51. doi: 10.1021/jm701494b. Epub 2008 Feb 5. Structure-based virtual screening for the discovery of natural inhibitors for human rhinovirus coat protein.

Rollinger JM1, Steindl TM, Schuster D, Kirchmair J, Anrain K, Ellmerer EP, Langer T, Stuppner H, Wutzler P, Schmidtke M. 1Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 52, A-6020 Innsbruck, Austria. judith.rollinger@uibk.ac.at

Inhibitors of the human rhinovirus (HRV) coat protein are promising candidates to treat and prevent a number of upper respiratory diseases. The aim of this study was to find antiviral compounds from nature, focusing on the HRV coat protein. Through computational structure-based screening of an in-house 3D database containing 9676 individual plant metabolites from ancient herbal medicines, combined with knowledge from traditional use, we selected sesquiterpene coumarins from the gum resin asafetida as promising natural products. Chromatographic separation steps resulted in the isolation of microlobidene (1), farnesiferol C (2), farnesiferol B (3), and kellerin (4). Determination of the inhibition of the HRV-induced cytopathic effect for serotypes 1A, 2, 14, and 16 revealed a dose-dependent and selective antirhinoviral activity against serotype 2 for asafetida (IC50 = 11.0 microg/mL) and its virtually predicted constituents 2 (IC50 = 2.5 microM) and 3 (IC50 = 2.6 microM). Modeling studies helped to rationalize the retrieved results.

PMID: 18247552

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Common cold
Viral infection

Suppressions

Asafoetida

Commonsteps

References