Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L
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Exp Parasitol. 2012 May;131(1):130-2. doi: 10.1016/j.exppara.2012.02.019. Epub 2012 Mar 7.
Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L.
Santos KK1, Matias EF, Tintino SR, Souza CE, Braga MF, Guedes GM, Rolón M, Vega C, de Arias AR, Costa JG, Menezes IR, Coutinho HD.
- 1Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
Chagas disease is caused by Trypanosoma cruzi, being considered a public health problem. An alternative to combat this pathogen is the use of natural products isolated from fruits such as Eugenia uniflora, a plant used by traditional communities as food and medicine due to its antimicrobial and biological activities. Ethanolic extract from E. uniflora was used to evaluate in vitro anti-epimastigote and cytotoxic activity. This is the first record of anti-Trypanosoma activity of E. uniflora, demonstrating that a concentration presenting 50% of activity (EC(50)) was 62.76 μg/mL. Minimum inhibitory concentration (MIC) was ≤ 1024 μg/mL. Our results indicate that E. uniflora could be a source of plant-derived natural products with anti-epimastigote activity with low toxicity.
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