Immunol Allergy Clin North Am. 2015 May;35(2):303-19. doi: 10.1016/j.iac.2015.01.008. Epub 2015 Mar 3.

Anaphylaxis to drugs.

Kuruvilla M1, Khan DA2.

Atlanta ENT, 5555 Peachtree Dunwoody Rd, Suite 125, Atlanta, GA-30342, USA.

2 Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8859, USA. Electronic address: dave.khan@utsouthwestern.edu.

Abstract

Drug-induced anaphylaxis is a common cause of anaphylaxis and a leading cause of fatal anaphylaxis. Antibiotics, radiocontrast, and nonsteroidal anti-inflammatory drugs are commonly implicated drugs.

Vocal cord dysfunction can mimic anaphylaxis and is often overlooked. β-Lactams are a common cause of anaphylaxis; however, skin testing and drug challenge can usually determine tolerability of other classes of β-lactams.

Nonionic contrast agents cause anaphylaxis less frequently than ionic contrast, and immunoglobulin E-mediated mechanisms may have a role in some of these reactions. Skin testing with radiocontrast may have a role in evaluating patients with anaphylaxis to nonionic contrast.

Copyright © 2015 Elsevier Inc. All rights reserved.

KEYWORDS:

Anaphylaxis; Cephalosporin; Drug; NSAID; Penicillin; Proton pump inhibitor; Radiocontrast; Vocal cord dysfunction

PMID:

25841553