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Triprolidine (Actidil, Myidil) is a first generation antihistamine and an over-the-counter drug  used to combat the symptoms associated with allergies.  It has also combined with other cold medications designed to provide general relief for flu-like symptoms. As the marketing literature says…  “Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes”.  Hmmmmmmmmm.

What is perhaps of more interest is that Triprolidine was at one time one of the  active ingredients of Actifed.   This was at one time a combination antihistamine and nasal decongestant medication used for cold and allergy symptoms.  It was widely used ‘recreationally’.

The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Actifed's U.S. formula  was changed in late 2006 to contain chlorpheniramine maleate 4 mg as the antihistamine and phenylephrine HCl 10 mg as the nasal decongestant.

“Many users of the old formula have complained that the new formula is not as effective at relieving their symptoms”.

Other brands available behind the counter that use the old formula include Genac and Aprodine. The American pharmacy chain Walgreens produces a house-brand version of Actifed, Wal-Act, which uses the original pseudoephedrine/triprolidine formula.

In the UK, the product is still available as a pack of 12 tablets. Each tablet contains Triprolidine hydrochloride 2.5 mg and Pseudoephedrine hydrochloride 60 mg and is a Pharmacy-only medicine.  In Germany, the product is available under the registered trademark Rhino PRONT, as a Pack of 12 tablets with the same composition as in the UK. In Germany too this is a pharmacy-only medicine.

Actifed was included in the standard medical kit aboard the United States Apollo missions, and was used during Apollo 7 and Apollo 12 when crew members developed head cold symptoms. When Actifed was made available over-the-counter, former astronauts from the Apollo missions appeared in commercials promoting the product.

On Apr, 3, 2015: 13 people reported to have side effects when taking Triprolidine hydrochloride. Among them, 2 people (15.38%) have Death.

On Mar, 7, 2015: 546 people reported to have side effects when taking Actifed. Among them, 6 people (1.10%) have Death.

On Apr, 3, 2015: 546 people reported to have side effects when taking Actifed. Among them, 11 people (2.01%) have Hallucination.

Time on Actifed when people have Hallucination  :