Iran J Allergy Asthma Immunol. 2015 Apr;14(2):222-7.

Vitamin d deficiency in chronic idiopathic urticaria.

Movahedi M1, Tavakol M2, Hirbod-Mobarakeh A3, Gharagozlou M1, Aghamohammadi A4, Tavakol Z5, Momenzadeh K6, Nabavi M7, Dabbaghzade A1, Mosallanejad A8, Rezaei N9.

• 1Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 2Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran marzieh.tavakol@yahoo.com.
• 3Molecular Immunology Research Center, Department of Immunology, School of Medicine, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 4Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran and Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 5Student' Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran marzieh.tavakol@yahoo.com.
• 6Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 7Department of Allergy and Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 8Imam Hosein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.
• 9Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran and Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran marzieh.tavakol@yahoo.com.

Chronic urticaria is the most common skin diseases, characterized by chronic cutaneous lesions which severely debilitates patients in several aspects of their everyday life. Vitamin D is known to exert several actions in the immune system and to influence function and differentiation of mast cells, central role players in the pathogenesis of chronic idiopathic urticaria. This study was performed to evaluate the relationship between vitamin D levels and susceptibility to chronic idiopathic urticaria. One hundred and fourteen patients with chronic idiopathic urticaria were recruited in this study along with one hundred and eighty seven sex-matched and age-matched healthy volunteers as the control group. For each patient, urticaria activity score was calculated and autologous serum skin test was done. Vitamin D metabolic statue was measured in serum as 25 hydroxyvitamin D using enzyme immunoassay method.  Patients with chronic idiopathic urticaria significantly showed lower levels of vitamin D. Vitamin D deficiency was significantly associated with increased susceptibility to chronic idiopathic urticaria. There was a significant positive correlation between vitamin D levels and urticaria activity score. This study showed that patients with chronic idiopathic urticaria had reduced levels of vitamin D, while vitamin D deficiency could increase susceptibility to chronic idiopathic urticaria.

PMID:  25780889