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Trypanocidal activity of oleoresin and terpenoids isolated from Pinus oocarpa
Identifier
017483
Type of Spiritual Experience
Background
Pinus oocarpa is a species of pine tree native to Mexico and Central America. It is the national tree of Honduras, where it is known as Ocote. Common names include pino amarillo, pino avellano, Mexican yellow pine, and hazelnut pine. It appears that it was the progenitor (original) species that served as the ancestor for some of the other pines of Mexico.
Lomatiums also have high levels of longifolene so we have added the link to them as well
A description of the experience
Z Naturforsch C. 2005 Sep-Oct;60(9-10):711-6.
Trypanocidal activity of oleoresin and terpenoids isolated from Pinus oocarpa.
Rubio J1, Calderón JS, Flores A, Castroa C, Céspedes CL.
- 1Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. juruli@servidor.unam.mx
Abstract
Fractionation with n-hexane/ethyl acetate (1:1 v/v) by open column chromatography of the oleoresin from Pinus oocarpa Schiede yielded
- two diterpenes, pimaric acid (1) and dehydroabietic acid (5),
- the sesquiterpene longifolene (3) and
- a diterpenic mixture containing pimaric acid (1), isopimaric acid (4) and dehydroabietic acid (5).
Subsequently, the isolated compounds, the mixture of 1, 4 and 5, the oleoresin and the dehydroabietic acid methyl ester (2), were tested in vitro against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas disease.
The most active compounds were 1, 3 and the oleoresin, being as active as nifurtimox, a drug effective in the treatment of acute infection by American trypanosomiasis and used in this work as positive control.
PMID: 16320613