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Senna leaf extracts induced Ca+2 homeostasis in a zoonotic tapeworm Hymenolepis diminuta



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A description of the experience

Pharm Biol. 2016 Feb 15:1-5. [Epub ahead of print]

Senna leaf extracts induced Ca+2 homeostasis in a zoonotic tapeworm Hymenolepis diminuta.

Roy S1, Kundu S1, Lyndem LM1.

  • 1a Parasitology Research Laboratory, Department of Zoology , Visva-Bharati University , Santiniketan , West Bengal , India.


Context Plants and plant products have been used in traditional medicine as anthelmintic agents in human and veterinary medicine. Three species of Senna plant, S. alata (L), S. alexandrina (M) and S. occidentalis (L.) Link (Fabaceae) have been shown to have a vermicidal/vermifugal effect on a zoonotic tapeworm Hymenolepis diminuta (Rudolphi) (Cyclophyllidean).

Objective The present study validates the mode of action of these Senna plants on the parasite. The alcoholic leaf extract was determined to obtain information on the intracellular free calcium concentration level.

Materials and methods Hymenolepis diminuta was maintained in Sprague-Dawley rat model for 2 months. Live parasites collected from infected rat intestine were exposed to 40 mg/mL concentration of each plant extracts prepared in phosphate buffer saline at 37 °C, till parasite gets paralyzed. The rate of efflux of calcium from the parasite tissue to the medium and the level of intracellular Ca2+ concentration were determined by an atomic absorption spectroscopy.

Results This study revealed that exposure of the worms to the plant extract leads to disruption in intracellular calcium homeostasis. A significant increase (44.6% and 25%) of efflux in Ca2+ from the tissue to the incubated medium was observed. Senna alata showed high rate of efflux (5.32 mg/g) followed by S. alexandria and S. occidentalis (both 4.6 mg/g) compared with control (3.68 mg/g).

Discussion and conclusion These results suggest that leaf extracts caused membrane permeability to Ca2+ after vacuolization of the tegument under stress and the extracts may contain compound that can be used as a chemotherapeutic agent.


Anthelmintic; calcium; efflux; helminth; paralysis; parasite; tegument; vacuolization



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