Formation of scopolamine from N-butyl-scopolammonium bromide in cigarettes
Type of Spiritual Experience
Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan, is a medication used to treat crampy abdominal pain, renal colic, and bladder spasms.
A description of the experience
J Anal Toxicol. 2007 May;31(4):220-3.
Formation of scopolamine from N-butyl-scopolammonium bromide in cigarettes.
Frascht M1, Schneider S, Schuman M, Wennig R.
- 1National Health Laboratory, Toxicology Division, Luxembourg.
Scopolamine (hyoscine) is a naturally occurring alkaloid found in solonacea, the so-called "night shade" plants. Therapeutic applications of scopolamine are in ophthalmology to cause mydriasis and for the prevention of motion sickness, among others. It is known to induce hallucinogenic effects at a high dose. The N-butyl bromide derivative of scopolamine, available commercially as Buscopan, is commonly used as an antispasmotic. The possibility of forming scopolamine from N-butyl-scopolammonium bromide when burning cigarettes fortified with Buscopan was investigated based on a record of a prison inmate who claimed to experience hallucinations after smoking Buscopan. Liquid chromatography-tandem mass spectrometry in electrospray ionization mode was used to monitor the formation of scopolamine. Various series of eight cigarettes spiked with 10 mg of N-butyl-scopolammonium bromide with and without filters and in different smoking modes were investigated. The smoke of the burning cigarettes, the ashes, and the filter were analyzed for the presence of scopolamine. Scopolamine was detected in all cases.
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps
OverloadsBladder and urinary tract disease
Urinary and bladder control treatments