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Observations placeholder

Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Identifier

017876

Type of Spiritual Experience

Background

A description of the experience

Evid Based Complement Alternat Med. 2013;2013:860602. doi: 10.1155/2013/860602. Epub 2013 Aug 25.

Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints.

Beer AM1, Neff A.

  • 1Department of Naturopathy, Blankenstein Hospital, Im Vogelsang 5-11, 45527 Hattingen, Germany.

Abstract

Past reviews on Cimicifuga racemosa (CR) without differentiation between extracts, quality, and indication altogether led to inconsistent data. Therefore, for the first time, we meet the requirements of the system's logic of evidence-based phytotherapy by taking into consideration extracts, pharmaceutical quality (reflected in a regulatory status as medicinal product), and indication.

A literature search for clinical studies examining CR's efficacy and safety for menopausal complaints was conducted.

The results were sorted by type of extract, regulatory status, and indication. Accordingly, Oxford Levels of Evidence (LOE) and Grades of Recommendation (GR) were determined.

CR extracts demonstrated a good to very good safety in general, on estrogen-sensitive organs and the liver.

However, only registered CR medicinal products were able to prove their efficacy.

Best evidence was provided by the isopropanolic CR extract (iCR): the multitude of studies including more than 11,000 patients demonstrated consistent confirmatory evidence of LOE 1b (LOE 1a for safety) leading to GR A. The studies on the ethanolic extract BNO 1055 including more than 500 patients showed exploratory evidence of LOE 2b resulting in GR B.

A positive benefit-risk profile is stated and limited to Cimicifuga racemosa products holding a marketing authorisation for treating climacteric complaints.

PMID:  24062793

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Estrogen imbalance
Menopause

Suppressions

Black cohosh

Commonsteps

References