Observations placeholder
Children, epilepsy and anaesthetics
Identifier
006790
Type of Spiritual Experience
Background
Sodium thiopental, better known as Sodium Pentothal, thiopental, thiopentone sodium, or Trapanal, is a rapid-onset short-acting barbiturate general anaesthetic.
A description of the experience
Arq Neuropsiquiatr. 2000 Jun;58(2A):282-7. [Comparative non-randomized study with midazolam versus thiopental in children with refractory status epilepticus]. [Article in Portuguese] Löhr A Jr, Werneck LC
We evaluated the use of midazolam versus thiopental in 50 children with refractory status epilepticus (RSE), admitted in a pediatric intensive care unit. The study consisted of two groups of patients:
- Group A - Midazolam, a prospective study, and
- Group B - Thiopental, a historical group.
These patients already had previous medication with benzodiazepin and diphenylhydantoin and other drugs.
- When there was no effective control of the seizures, the patients of Group A received midazolam of 200 microg/kg intravenous in bolus, being followed by continuous intravenous infusion at the rate 0. 25-15 microg/kg/min.
- Group B received thiopental 1 mg/kg intravenous in bolus followed by continuous intravenous infusion at the rate of 10-120 microg/kg/min.
In relation to the time of seizure control and effectiveness, there was no statistical significance for the two groups. The Midazolam Group had significantly less complications during the treatment: less cyanosis (p=0.00006), and they did not need respiratory support (p<0.00001).
When the therapy with midazolam was ceased, 12.5% of the patients from this group showed psychological disorders such as mental confusion, aggressive behavior, restlessness, hallucinations and agitation.
PMID: 10849628
The source of the experience
PubMedConcepts, symbols and science items
Concepts
Symbols
Science Items
Activities and commonsteps
Activities
Overloads
BarbituratesBeing anaesthetised
Benzodiazepines
Epilepsy