Children, epilepsy and anaesthetics
Type of Spiritual Experience
Sodium thiopental, better known as Sodium Pentothal, thiopental, thiopentone sodium, or Trapanal, is a rapid-onset short-acting barbiturate general anaesthetic.
A description of the experience
Arq Neuropsiquiatr. 2000 Jun;58(2A):282-7. [Comparative non-randomized study with midazolam versus thiopental in children with refractory status epilepticus]. [Article in Portuguese] Löhr A Jr, Werneck LC
We evaluated the use of midazolam versus thiopental in 50 children with refractory status epilepticus (RSE), admitted in a pediatric intensive care unit. The study consisted of two groups of patients:
- Group A - Midazolam, a prospective study, and
- Group B - Thiopental, a historical group.
These patients already had previous medication with benzodiazepin and diphenylhydantoin and other drugs.
- When there was no effective control of the seizures, the patients of Group A received midazolam of 200 microg/kg intravenous in bolus, being followed by continuous intravenous infusion at the rate 0. 25-15 microg/kg/min.
- Group B received thiopental 1 mg/kg intravenous in bolus followed by continuous intravenous infusion at the rate of 10-120 microg/kg/min.
In relation to the time of seizure control and effectiveness, there was no statistical significance for the two groups. The Midazolam Group had significantly less complications during the treatment: less cyanosis (p=0.00006), and they did not need respiratory support (p<0.00001).
When the therapy with midazolam was ceased, 12.5% of the patients from this group showed psychological disorders such as mental confusion, aggressive behavior, restlessness, hallucinations and agitation.
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps