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Observations placeholder

Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae

Identifier

023833

Type of Spiritual Experience

Background

A description of the experience

Chem Pharm Bull (Tokyo). 2012;60(2):178-82.  Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae.  Wu HQ1, Li L, Li J, He ZD, Liu ZG, Zeng QQ, Wang YS.  1College of Life Sciences, Shenzhen University, Shenzhen, China. wuhq@szu.edu.cn

This study characterized the acaricidal activity of constituents of patchouli oil extracted from (Pogostemon cablin (Blanco) BENTH) against the house dust mite, Dermatophagoides farinae.

A new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (DHEMH), was isolated from patchouli oil and characterized by (1)H-NMR, (13)C-NMR, LC-MS and elemental analysis (EA). This active component was identified as the hydrolysate of pogostone. Fifteen other constituents found in patchouli oil were also identified by GC-MS, including patchouli alcohol and pogostone.

LD(50) studies carried out over 24 h using contact toxicity tests identified DHEMH as the most toxic compound to D. farinae (2.04 μg/cm(2)), followed by patchouli oil (6.11 μg/cm(2)), benzyl benzoate (BP) (9.31 μg/cm(2)) and dibutyl phthalate (DBP) (58.52 μg/cm(2)).

In vapor phase toxicity tests, all of these compounds were more effective in closed than open containers, indicating that the most efficient mode of delivery for these compounds is the vapor phase. These results indicate that DHEMH and patchouli oil merit further study as potential agents for the control of D. farinae.

PMID: 22293476

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Mites

Suppressions

Essential oils
Patchouli

Commonsteps

References