A novel protocol for postpartum magnesium sulphate in severe pre-eclampsia: a randomized controlled pilot trial
Type of Spiritual Experience
A description of the experience
J Matern Fetal Neonatal Med. 2016;29(1):154-8. doi: 10.3109/14767058.2014.991915. Epub 2014 Dec 23.
A novel protocol for postpartum magnesium sulphate in severe pre-eclampsia: a randomized controlled pilot trial.
El-Khayat W1, Atef A1, Abdelatty S2, El-Semary A1.
Magnesium sulphate is the preferred anticonvulsant used to prevent the development of fits in severe pre-eclampsia; we aim to compare between three different protocols of postpartum magnesium sulphate in the effectiveness of preventing the development of fits in severe pre-eclampsia.
Double-blind randomized controlled pilot trial, done in Cairo university hospital, Cairo, Egypt during 2013-2014, on 240 women with severe pre-eclampsia. Magnesium sulphate intravenous infusion was given in the postpartum period to all the patients, women were randomly allocated to group I (Single loading dose only), group II (12 h abbreviated protocol) or group III (24 h standard protocol) (n = 80 in each group).
There were no significant difference between the three groups as regards the incidence of eclampsia, elevated liver enzymes and low platelets syndrome, maternal ICU admission and; however The incidence of flushing was significantly higher in group III than group II and I (24 [30%] versus 12 [15%] versus 4 [5%]; p < 0.001) respectively.
The pilot study demonstrates that the single-loading dose of postpartum magnesium sulphate is a promising alternative to the standard and the abbreviated protocol in preventing eclampsia; however, a large clinical trial is necessary to prove this.
Abbreviated regimen; eclampsia; magnesium sulphate; pre-eclampsia