Some science behind the scenes

Biguanides

The biguanide class of anti-diabetic drugs, originates from the French lilac (Galega officinalis), a plant used in folk medicine for several centuries. Biguanides reduce hepatic glucose output and increase uptake of glucose by the periphery, including skeletal muscle. There are three main drugs within this category 

  • Metformin (Glucophage) .

  • Phenformin (DBI) was used from 1960s through 1980s, but was withdrawn due to lactic acidosis risk.

  • Buformin also was withdrawn due to lactic acidosis risk.