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Muscle relaxants

Category: Medicines

Type

Involuntary

Introduction and description

 In the section on muscle diseases we have looked at the causes of these diseases - viruses, toxins, damage caused by surgery or accident, bacteria, fungi, parasites, radiation and pharmaceuticals.

A muscle relaxant is a pharmaceutical that is designed to treat the symptoms of muscle diseases.  These class of drugs are not designed to cure, simply because they do not address the cause.  According to Wikipedia

A muscle relaxant is a drug which affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeutic groups:

  • Neuromuscular blockers - Neuromuscular blockers act by interfering with transmission at the neuromuscular end plate and have no central nervous system (CNS) activity. They are often used during surgical procedures and in intensive care and emergency medicine to cause paralysis
  • Spasmolytics -  Spasmolytics, also known as "centrally-acting" muscle relaxants, are used to alleviate musculoskeletal pain and spasms and to reduce spasticity in a variety of neurological conditions.

While both neuromuscular blockers and spasmolytics are often grouped together as muscle relaxants, the term is commonly used to refer to spasmolytics only. 

sometimes the cause is a bit more difficult to address

In this section we will use this convention and only look at spasmolytics, simply because it is these drugs that have the record of producing spiritual experiences.

Muscle relaxants may help with acute musculoskeletal pain, when physical therapy is unavailable or has not been fully successful. Applicable conditions include acute back or neck pain, or pain after an injury.  They may also be used to treat spasms associated movement disorders in neurologic conditions such as cerebral palsy, multiple sclerosis, and spinal cord disease.   It is worth adding that although medications are commonly used for ‘spastic movement’ disorders, research has not shown functional benefit for some of these drugs. Some studies have shown that medications have been effective in decreasing spasticity, but that this has not been accompanied by functional benefits.

Categories of drugs

There are various classes of drugs within this category :

  • Mixed receptor - First there are some that appear to have multiple receptor activity, which means that they will not only act on the muscle to relax it but may have  numerous other actions as well via the other receptors e.g. Baclofen, Metaxalone, Tizanidine
  • Anticholergens - Then there are a three anticholinergic based drugs that work principally via the muscarinic receptors  -  Cyclobenzaprine, Orphenadrine and Flavoxate
  • Benzodiazepines – there are a number of benzodiazepines that are used as muscle relaxants, but I have excluded them from this description as they have their own section e.g. Bentazepam, Diazepam, Lorazepam, Nitrazepam, and Tetrazepam
  • ‘Carbamic acid esters’ – these too usually have multiple receptor activity and occasionally it is not clear that all the receptors have been identified or are known.  For example  - Carisoprodol, Febarbamate, Meprobomate, Methocarbamol, Phenprobamate, Styramate

 Side effects

In June 2016, eHealthme ceased to provide the information on which all the data in this section is based.  On querying my friends in the USA, it would seem that many of the sites that provided similar information, have done the same.  The links we provided to eHealthme also no longer work as this data too has been removed. 

As to why all these sites have removed exceptionally important information, my USA helpers said that more and more people are questioning what they are being given – and demanding to know WHY the CAUSE of their illness has not been investigated.  It appears that there has been a very heartening increase in the numbers of people who want to be healed – have the cause tackled and not the symptoms.  And this is ‘not popular’ with the conventional medical community, who cannot make money from well people.

The statistics collected from eHealthme remain valid for the date they were collected.  As such we have left this section as it is – an historical record.  Please read this section therefore only as an historical record of the figures that were applicable on the date specified.

If we take at random one example drug such as Zanaflex, according to the Adverse Drug reports they have collated, the most common side-effects reported are shown  below

 
Female Male
Pain Depression
Nausea Anxiety
Fall Pain
Fatigue Back Pain
Headache Fatigue
Asthenia Asthenia
Chest Pain Drug Ineffective
Depression Drug Dependence
Anxiety Nausea
Dyspnoea Hypoaesthesia

In addition to the side effects above, there is of course the ultimate spiritual experience - death.  If we take again some of the main drugs in this category, the list that follows shows the figures from the eHealthme site.  Please note that this list does not include every drug.  The observations for each drug do, however, include figures:

Lioresal - On Jun, 1, 2015: 11,921 people reported to have side effects when taking Lioresal. Among them, 449 people (3.77%) have Death.

Trend of Death in Lioresal reports

Baclofen - On Jun, 23, 2015: 20,415 people reported to have side effects when taking Baclofen. Among them, 359 people (1.76%) have Death.

Trend of Death in Baclofen reports

Flexeril - On Jun, 5, 2015: 14,482 people reported to have side effects when taking Flexeril. Among them, 226 people (1.56%) have Death.

Trend of Death in Flexeril reports

 Soma - On Jun, 16, 2015: 8,631 people reported to have side effects when taking Soma. Among them, 117 people (1.36%) have Death.

Trend of Death in Soma reports

Zanaflex - On Jun, 7, 2015: 6,740 people reported to have side effects when taking Zanaflex. Among them, 73 people (1.08%) have Death.

Trend of Death in Zanaflex reports

Methocarbamol - On Jun, 21, 2015: 2,773 people reported to have side effects when taking Methocarbamol. Among them, 42 people (1.51%) have Death.

Trend of Death in Methocarbamol reports

 Skelaxin - On Jun, 26, 2015: 5,162 people reported to have side effects when taking Skelaxin. Among them, 54 people (1.05%) have Death.

Trend of Death in Skelaxin reports

 Metaxalone - On Jun, 26, 2015: 864 people reported to have side effects when taking Metaxalone. Among them, 25 people (2.89%) have Death.

Trend of Death in Metaxalone reports

Meprobamate -  On Jun, 8, 2015: 1,508 people reported to have side effects when taking Meprobamate. Among them, 53 people (3.51%) have Death.

Trend of Death in Meprobamate reports

Equanil - On Jun, 26, 2015: 1,192 people reported to have side effects when taking Equanil. Among them, 37 people (3.10%) have Death.

Trend of Death in Equanil reports

How it works

 

There is no one way in which these pharmaceuticals exert their hallucinatory effects.  Furthermore, there are drugs on this list where the manufacturers of them do not know what is in them.  Some of them appear to 'work' via the GABAA receptor and thus we can look for their effects by examining the section on the GABA receptor.  One 'works' via the NMDA receptor, yet others via the muscarinic receptors.  I refer you to the main sections on each of these receptors to understand how they may execute their hallucinatory effect.

But if one was to step back and analyse things in a less 'receptor' oriented way, one would have to come to the conclusion, that they gave people hallucinations because they were toxic to them.

References and further reading

This is worth reading -Killed My Inner Self-Ephedrine, Baclofen & Diazepam by kt; no hallucinations just a message to the FDA and doctors everywhere.

 

Observations

The table below has been derived from the figures on eHealthme and was correct as at mid 2015.  The link takes you to the eHealthme website where you can view current figures for hallucinations and deaths and see all the other side-effects.

Observation no

Name of pharmaceutical

No of hallucinations

 016874

 Zanaflex

 159

 016875

 Tizanidine

 11

016878

 Orphenadrine

 19

 016879

 Norflex

 18

 016880

 Methocarbamol

 29

 016881

 Robaxin

 31

 016882

 Skelaxin

 80
 016883  Metaxalone  11
 016884  Meprobamate  10
 016885 Equanil 9
 016886  Flavoxate  4
 016887  Dantrolene Sodium  4
 016888  Flexeril  231
 016889  Cyclobenzaprine  9
 016891  Carisoprodol  14
 016892  Soma  111
 016893  Baclofen  300
 016894  Lioresal  132
  Total  1,182

 

 

 

Related observations

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Hallucination

Wisdom, Inspiration, Divine love & Bliss

Out of time

Near death, Out of time, Out of body, Rebirth

In time

Synaesthesia, Pure or enhanced perception, Inter composer communication, Vision, Dream, Perception recall, Exploring group perception