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Brain tumour

Category: Illness or disabilities

Type

Involuntary

Introduction and description

A brain tumor (or brain tumour) is an abnormal growth of cells within the brain or the central spinal canal. They are caused by abnormal and uncontrolled cell division, in the brain itself, in the cranial nerves, in the brain envelopes, skull, pituitary and pineal gland. Any brain tumor is inherently serious and life-threatening because it is invasive and because of the limited space of the intracranial cavity. They can be cancerous (malignant) or non-cancerous (benign).

Tumours may originate from the brain itself or can originate from cancers located in other organs. Cancer cells can ‘leak’ from a primary tumour and then enter the lymphatic system and blood vessels. They then circulate through the bloodstream, and are deposited in the brain. There, these cells continue growing and dividing; the most common types of cancers that bring about secondary tumours of the brain are lung cancer, breast cancer, malignant melanoma, kidney cancer and colon cancer (in decreasing order of frequency).

Because the brain is hidden by the skull, the early detection of a brain tumour only occurs when diagnostic tools are directed at the intracranial cavity. Usually detection occurs in advanced stages when the presence of the tumour has caused unexplained symptoms.

Symptoms

Lucy Goulding, 16, died of an undiagnosed brain tumour after

her GP sent her away four times saying she was suffering from

migraines caused by stress.

The symptoms of a brain tumour depend on its location type and size. One of the first noticeable symptoms is due to the extra pressure the tumour creates as it grows. The person may get headaches, may vomit, have dilated pupils and become sleepy, bemused or go into a coma.

Headaches are the first noticeable symptom for about 20% of all people with brain tumours. Over 60% to 70% of all patients experience headaches at some point in the course of their illness.

The headache may be on the same side of the head as the tumour, or may occur elsewhere on the head. This happens because the pain is ‘referred’ to other areas of the head. [Referred pain is pain that is felt somewhere different from where it originates]. Headaches are often worse in the morning after laying flat all night, because pressure in the brain increases when the head is down. They may also be worse with exertion. Most patients experience nausea and vomiting with the headache. If the tumour is obstructing the ventricles (structures that contain the cerebrospinal fluid), the headache may get worse when the person changes position.

Where the tumour damages surrounding brain tissue via the compression or the infiltration of cells, there may also be all sorts of cognitive and behavioural changes – impaired judgement, memory loss, inability to recognise things, and spatial orientation mistakes. It may be very difficult for some people to engage in abstract reasoning, and some people may not be able to make decisions.

The effects depend on the location of the damage.

Martin Kemp had a brain tumour ""The diagnosis of a brain tumour is

devastating. But if a tumour is found in time and you are given the right

treatment, you can survive and live life to the full."

There may be changes in the personality and emotional changes. There may also be a number of problems with the senses such as a loss of the sense of smell or taste, or hearing, or sight impairments [double vision, blurred vision etc] and touch sensation loss or loss of feeling in various parts of the body – numbness or paralysis; and there may be any number of problems with co-ordination and muscle control. There may in addition be severe problems with language and speech ranging from having difficulty remembering words to being completely unable to speak, read, or write. People may also become irritable with abnormal fatigue, weariness, absences and tremors.

Elizabeth Taylor had Meningioma

Perhaps of particular interest is that they can also suffer from epileptic seizures giving us a link to epilepsy as a source of spiritual experience. A seizure is a sudden, brief attack of uncontrolled motor activity. Seizures occur in approximately 35% of all brain tumour patients. The probability of having a seizure depends on the location of the tumour, as some parts of the brain are more prone to seizure activity than others.

Causes

Although a doctor is likely to say a tumour is caused by abnormal growth of a cell, this is not the cause. This is simply a statement of a symptom. In order to find the true cause of a brain tumour one has to go back into the cause effect chain, and we find the same root causes as those that cause other brain conditions - brain damage. The following is a long, but as complete a list as I can ascertain at the moment, from all the research.

Physical injury and surgery

Julian Huxley was diagnosed with a brain tumour after a 'routine scan'

There is a clear link with having had a brain injury and/or surgery and the development of a tumour. The type of injury appears to be key, an open wound appears to be statistically more likely to produce tumours than concussion for example. The reason may be that infection has entered the head prior to the wound healing - bacteria or even viral infection, as two reasons for brain tumour are bacteria and viruses. There is also a key point of entry for pathogens of all sorts via the nose [which is a very vulnerable spot] and the blood brain barrier. A broken nose may appear harmless, but if it allows pathogens to enter, the long term consequences may be severe.

Inherited genes

Recent advances in mapping of the human genome have identified a weak genetic link in patients with brain tumours. But this is not a cause. What caused the faulty gene?

Scientists appear not to know. But the following may be responsible...... classified as a toxin, - the nanoparticle - invented by scientists and being released into the environment by scientists in the belief that they do no harm, except that yet other researchers have realised they do a lot of harm......

....DNA damage occurs chemically or physically by nanomaterials. Chemical and physical damage are associated with point mutation by free radicals and double strand brake, respectively. The failure of DNA repair and accumulation of mutations might occur when inflammation is prolonged, and finally normal cells could become malignant. These free radicals can not only damage cells but also induce signaling molecules containing immunoreaction. Nanoparticles and asbestos also induce the production of free radicals. .... Taken together,... a variety of diseases [may be] induced by nanomaterials. PMID: 25097864

Parasites

Ted Kennedy, the politician died of a

brain tumour

The role of parasites in developing countries in producing blindness and sight impairment is well-known. But parasites - and very often the same parasites, can produce brain tumours. Parasites can get everywhere in the body, as such the same parasite causing one group of cancers could easily cause brain tumours.

Chronic infections including the cysticercosis induce inflammatory cells to produce free radicals and synthesize carcinogenic toxins. The cells with genetic mutations proliferate in a disorganized manner, leading to the development of neoplasia. ..... Patients autopsied were divided into 4 groups: patients with neoplasia and cysticercosis (NC), patients with neoplasia only (NN), patients with cysticercosis only (CC), and patients without neoplasia or cysticercosis (WW). Of 2012 autopsy reports analyzed, 0.4 showed NC. In groups CC and NC, the most common location of the parasite was the brain. There was a predominance of three or more cysticerci in groups NC and CC. In the NC group, all had malignant neoplasms, and was predominance of benign neoplasm in NN group. The digestive system was the most frequent neoplasia. PMID: 24288510

Mo Mowlam, the UK MP, kept her malignant tumour,

diagnosed early in 1997, a secret until her death

in August 2005.

Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family - see Being with cats.

Another serious carrier of parasites is the fox which spreads Echinococcosis. In countries where dogs and cats are not wormed and their faeces safely disposed of, domestic dogs and cats can also be a problem. This parasite can also cause brain damage.

Toxins and heavy metals

There is a very clear link between toxins of all sorts - from pesticides to insecticides, from household chemicals to herbicides - and brain damage.

The evidence seems to point to high intensity and prolonged exposure being particularly significant, however, there are case studies on PubMed, of people who had one-off exposures that led to subsequent tumours. ......

BACKGROUND: The atmosphere of valley of Kashmir is ideal for fresh and dry fruit production. Millions of tons of pesticides, insecticides and fungicides (chemicals like chlorpyriphos, mancozeb, captan, dimethoate, phosalone, etc.) are being used by the orchard farmers to spray the plants, fruits and the leaves every year. The increasing trend in the incidence of primary malignant brain tumors in orchard farmers of Kashmir is alarming.
AIM: To determine the relationship between the patients of primary malignant brain tumors and their occupation.
MATERIALS AND METHODS: Retrospectively case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases), admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Department of Neurosurgery, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Kashmir, were studied. ....
RESULTS: Analysis revealed that 90.04% (389 out of 432) patients were orchard-farm workers, orchard residents and orchard playing children exposed to the high levels of multiple types of neurotoxic and carcinogenic (chlorpyriphos, dimethoate, mancozeb and captan) chemicals ......
CONCLUSION: All orchard-related 389 patients had high grade tumors... Mortality in pesticide exposed tumors was 12%. Higher levels of SCE were found in 31.9% (124 out of 389) patients and decreased levels in only 45.3% (176 out of 389) orchard-related patients. PMID: 21584215

Another area of concern and again with proven links to brain damage, is the presence of lead and mercury as well as other heavy metals in the body.

But are they safe?..........

The picture below shows the brain volume and damage found in subjects with childhood lead exposure [Cecil 2008:3].

The red and yellow clusters mark areas of significantly reduced brain volume as well as damage.

In this we should not forget the role of dental amalgam fillings, as they are mercury based.

Where a filling is leaking or poor dental work has been undertaken, then the mercury may be the cause.

There are also other sources of mercury - one of which is vaccines, of which more in a moment.

Combining estimates of the incidence/prevalence/distribution of different conditions or exposures with estimates, derived from meta-analyses, for the impact of different risk factors on children's Full-Scale IQ scores (FSIQ), the total FSIQ losses associated with each were calculated for the U.S. population of children less than 5 years of age. The losses associated with non-chemical risk factors ranged widely: 34,000,000 FSIQ points for preterm birth, 17,000,000 for Attention Deficit Hyperactivity Disorder, 9,000,000 for iron deficiency, 136,000 for acute lymphocytic leukemia, and 37,000 for brain tumors. The FSIQ losses could be estimated for three chemicals: lead, 23,000,000 points; methylmercury, 285,000 points; and organophosphate pesticides, 17,000,000 points. Many caveats attend these calculations, but the findings suggest that in continuing to apply standards appropriate to evaluating the impact of chemical exposures on an individual child rather than on the population as a whole, we risk underestimating the population burdens associated with them. PMID: 22525934

Taking drugs

Whether a drug is legal or illegal seems to be a little arbitrary, however, the taking of presently illegal drugs causes various sorts of brain damage. The damage appears to be much greater when the drugs have been adulterated, as many drugs bought off the street often are. The following shows the link with brain damage, but the researchers did not investigate any further the link between the brain tumour and the cocaine use, which is a shame.

Cocaine abuse has been associated with a variety of intracranial haemorrhagic disorders, such as intracerebral, subdural or subarachnoidal haemorrhage. Frequently, these patients harbour underlying vascular malformations, like cerebral aneurysms or arteriovenous malformations (AVM). To the best of our knowledge only two cases of tumoral haemorrhage induced by cocaine abuse have been previously reported. We describe a new case of intracerebral haemorrhage after cocaine inhalation, in which both the preoperative imaging studies and the pathological examination showed a brain tumour as the origin of the haemorrhage. We think that cocaine abuse may be considered as a new precipitating factor in intratumoral haemorrhage. PMID: 15756411

Pharmaceuticals

The eHealthme site is the site that I use to obtain information on Adverse Drug reports submitted to the FDA and SEDA. These reports are not anecdotal, but cases where a definite link has been made between a pharmaceutical and a specific symptom. There are two symptoms on eHealthme related to brain tumour. As I write this no association has been made with any pharmaceuticals, however, if you glance at the other brain damage diseases you will find there is a clear association with quite a number of drugs. As such I will leave the link in place here so that you can check for the most up-to-date information:

- Brain tumour

- Brain tumour metastastic

Please note that we have been having trouble with broken links from this site as they reorganise entries. If these links no longer work, go to the mian site and search under the conditions.

Nutritional deprivation

Vitamin imbalance - both overload and deficiency as well as Mineral imbalance - overload and deficiency can result in brain damage of various sorts. There is thus the possibility that brain tumours may also be linked to nutritional deprivation.

There is a direct link between supplements [overdosing] and cataracts, for example, as such we should be vigilant in the area of brain tumours as well. There appears to be a well defined link with cancers of all sorts and fluoride imbalance, overdosing again via water supplies. Thus the case for overdosing as a cause looks quite strong.

The papers on vitamin or mineral deficiency are scarce. Although there are numerous papers showing that children and adults can be mineral and vitamin deficient after treatment for brain tumors, no measurements seem to being taken of people's nutritional status at the time they are diagnosed. In effect, what I am saying is there is no evidence at the moment, but that is because no one has actually done any measuring one way or another.

Bacterial infection

Russell Watson the singer has been attacked

twice by a brain tumour, coincidentally he lives in

an area where water is fluoridated

There is strong evidence that bacterial infection can cause some brain tumours. One culprit appears to be Pseudomonas aeruginosa, which is a common bacterium that can cause disease in many animals. It is found in soil, water, skin flora, and most man-made environments throughout the world. It thrives not only in normal atmospheres, but also in hypoxic atmospheres, and has, thus, colonized many natural and artificial environments. It uses a wide range of organic material for food; in animals, its versatility enables the organism to infect damaged tissues or those with reduced immunity. And here we see the link with wounds to the head or nose.

Ecthyma gangrenosum, presenting as embolic lesions caused by Pseudomonas aeruginosa infection, has distinct pathognomonic features and a high mortality rate in patients with bacteremia, but when recognized early is easily treated. In this case report we describe this disseminated infection in an adult patient treated with chemotherapy for an astrocytoma. PMID: 24979953

Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells, star-shaped brain cells in the cerebrum called astrocytes. This type of tumor does not usually spread outside the brain and spinal cord and it does not usually affect other organs.

Viral infection

Sheryl Crow has had a brain tumour

A growing number of viruses are implicated in brain damage ad brain tumours. Many viruses are able to pass through the blood brain barrier and attack the brain as well as nervous system and organs, as such they can be looked on as general pathogens that target various parts of the body somewhat indiscriminately. For example

Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents the most important flaviviral neural infection in Europe and northeastern Asia. In the central nervous system (CNS), neurons are the primary target for TBEV infection; however, infection of non-neuronal CNS cells, such as astrocytes, is not well understood. In this study, we investigated the interaction between TBEV and primary human astrocytes. We report for the first time that primary human astrocytes are sensitive to TBEV infection, ..... This is the first demonstration that TBEV infection activates primary human astrocytes. The infected astrocytes might be a potential source of proinflammatory cytokines in the TBEV-infected brain, and might contribute to the TBEV-induced neurotoxicity and blood-brain barrier breakdown that occurs during TBE. PMID: 25000960

Astrocytes are characteristic star-shaped glial cells in the brain and spinal cord. They are the most abundant cells of the human brain.

Fungal infection

Fungi can cause brain damage, as such one would expect that they might be implicated in brain tumours and it seems that the link here is begining to be investigated

Cryptococcus neoformans is the most common cause of fungal meningitis among individuals with HIV/AIDS, which is uniformly fatal without proper treatment. The underlying mechanism of disease development in the brain that leads to cryptococcal meningoencephalitis remains incompletely understood. We have previously demonstrated that inositol transporters (ITR) are required for Cryptococcus virulence. ....... Most of the significantly differentially expressed genes (SDEG) are part of immune cell networks such as tumor necrosis factor-alpha (TNF-¿) and interferon-gamma (IFN-¿) regulon PMID: 25201772

Other brain damage

Painting by John Currin

All of the other types of brain damage may degenerate into a tumour or even be the cause of a tumour, for example, Migraine, Bipolar disorder or manic depression, Parkinson’s disease, Multiple Sclerosis, ADHD, Brain haemorrhage, Concussion, Stroke, Meningitis, Traumatic injury to the brain and head banging, Encephalitis, Hydrocephalus, Epilepsy , Epidural hematoma and Atonia and atonic seizures. Brain tumours can develop in children with Autism.

Tuberous sclerosis complex (TSC) is a genetic condition with multisystem involvement, characterized by the development of tumors and other abnormalities in organs such as the brain, retina, skin, heart, kidneys, and lungs. Most patients have neuropathological abnormalities such as cortical tubers, white matter radial migration lines, subependymal nodules, and subependymal giant cell astrocytomas (SEGAs). These lesions are associated with different neurological manifestations that are frequently associated with TSC. These manifestations consist of epilepsy, intellectual disability, and neurobehavioral and psychiatric problems, including autism spectrum disorder. Hydrocephalus may also develop in patients with SEGAs due to ventricular obstruction, when this usually slow-growing tumor reaches sufficient size. PMID: 24771286

Vaccines

A subject to cause arguments in every camp. But there are proven cases where vaccines may cause brain damage of various sorts, and since viruses cause brain tumours, it is not difficult to see the link between vaccines and brain tumours.
Where the vaccine used in the injection is a live virus, there are instances where it, although apparently vanquished by the immune system, lays low and continues to attack, albeit at a much reduced rate. One example is the herpes virus, read on:

Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. From the DRG they can reactivate to cause human morbidity and mortality. Although they vary, in part, in the clinical disorders they cause, and in their molecular structure, they share several features that govern the biology of their infection of the human nervous system.
HSV-1 is the causative agent of encephalitis, corneal blindness, and several peripheral nervous system disorders;
HSV-2 is responsible for meningoencephalitis in neonates and meningitis in adults. The biology of their ability to establish latency, maintain it for the entire life of the host, reactivate, and cause primary and recurrent disease is being studied in animal models and in humans. PMID: 24142852

thus any vaccine containing a live virus carries great risk with it.

Some vaccines contain Thiomersal, which is mercury based. For a full list see this LINK. As a consequence, there is the risk of mercury poisoning and mercury poisoning can cause brain tumours.

Radiation

All radiation whether 'cosmic' or electromagnetic impacts our bodies and depending on its frequency it resonates different parts of us. The reason that nuclear radiation is so dangerous is that it impacts cells, but what we appear to have overlooked is that all radiation impacts some part of us.

Every aggregate in our bodies - organs, cells, the body itself, has natural ‘resonance’. Resonance is a substance’s natural tendency to oscillate – vibrate – at maximum amplitude at certain frequencies, known as the thing’s resonant frequency.

And the organs of the brain have a natural resonance, which, if it subjected to high intensity and fairly constant stimulation can cause brain tumours, for example.

A cohort of 4,400 persons treated for various cancers of childhood in France and the UK was followed up over an extended period to assess risks of subsequent brain tumour in relation to the radiotherapy and chemotherapy that the children received for their first cancer. .....There was also elevated brain tumour risk (two-sided p = 0.003) associated with ionising radiation exposure, the risk being concentrated among benign and unspecified brain tumours. The radiation-related risk of benign and unspecified brain tumours was significantly higher than that of malignant brain tumours (two-sided p< or =0.05); there was no significant change of malignant brain tumour risk with ionising radiation dose (two-sided p > 0.2). PMID: 9766556

How it works

Why do people get spiritual experiences from brain tumours? They can get hallucinations - visual and auditory, they can get sensory hallucinations and visions, they can get out of body experiences and even near death experiences.

In some cases a brain tumour simply works via hypoxia. Arterial and venous hypoxia, or the deprivation of adequate oxygen supply to certain areas of the brain, occurs when a tumor makes use of nearby blood vessels for its supply of blood and the neoplasm enters into competition for nutrients with the surrounding brain tissue.

Otherwise the cause is brain damage.

References and further reading

Indian J Med Paediatr Oncol. 2010 Oct;31(4):110-20. doi: 10.4103/0971-5851.76191. Pesticides and brain cancer linked in orchard farmers of Kashmir. Bhat AR1, Wani MA, Kirmani AR, Raina TH. 1Department of Neurosurgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Kashmir - 190011, India.
Kansenshogaku Zasshi. 2014 May;88(3 Suppl 9-10):37-9. Ecthyma gangrenosum caused by Pseudomonas aeruginosa in a patient with astrocytoma treated with chemotherapy. De Vos FY, Middelburg TA, Seynaeve C, de Jonge MJ.

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Brain tumour

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Introduction and description

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