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Observations placeholder

The Immune system and cannabis

Identifier

007599

Type of Spiritual Experience

Background

Thus the reason why cannabis helps those who are sick is in part due to the fact it boosts the immune system.

Furthermore, only the plant can do this, as the complexity of the receptors in our bodies and the complexity of the plant indicate that there is far more going on than any scientist has yet discovered - except that this group are wise enough to realise this and say so - in somewaht obscure language - but they do say it

'Development ..has been hampered by the complexity of their intracellular signaling, relative paucity of highly selective compounds and insufficient data regarding end effects in the target cells and organs'

which in layman's terms means we don't know what is going on and why it works.

A description of the experience

J Neuroimmune Pharmacol. 2013 Jun;8(3):608-20. doi: 10.1007/s11481-013-9445-9. Epub 2013 Mar 8.  Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation.  Rom S1, Persidsky Y.

An accumulating body of evidence suggests that endocannabinoids and cannabinoid receptors type 1 and 2 (CB(1), CB(2)) play a significant role in physiologic and pathologic processes, including cognitive and immune functions.

While the addictive properties of extracts from the Cannabis plant are well recognized, there is growing appreciation of the therapeutic potential of cannabis [the plant] in multiple pathologic conditions involving chronic inflammation:

  • inflammatory bowel disease
  • arthritis
  • autoimmune disorders
  • multiple sclerosis
  • HIV-1 infection
  • stroke
  • Alzheimer's disease

to name a few), mainly mediated by CB(2) activation. Development of CB(2) agonists as therapeutic agents has been hampered by the complexity of their intracellular signaling, relative paucity of highly selective compounds and insufficient data regarding end effects in the target cells and organs.

This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection.

PMID:  23471521

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Immune system

Activities and commonsteps

Commonsteps

References