The effect of selenium on carbendazim induced oral sub chronic toxicity
Type of Spiritual Experience
Carbendazim is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It is also employed as a casting worm control agent in amenity turf situations such as golf greens, tennis courts etc. and in some countries is licensed for that use only.
The fungicide is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It is also controversially used in Queensland, Australia on macadamia plantations.
A 4.7% solution of carbendazim hydrochloride, sold as Eertavas, is marketed as a treatment for Dutch elm disease.
Studies have found carbendazim causes infertility and destroys the testicles of laboratory animals.
"Maximum pesticide residue limits (MRLs) have reduced since discovering its harmful effects".
The MRLs for fresh produce in the EU are now between 0.1 and 0.7 mg/kg with the exception of loquat, which is 2 mg/kg. The limits for more commonly consumed citrus and pomme fruits are between 0.1 and 0.2 mg/kg.
A description of the experience
Environ Toxicol Pharmacol. 2014 Sep 20;38(3):711-719. doi: 10.1016/j.etap.2014.09.007. [Epub ahead of print]
Evaluation of ameliorative potential of selenium on carbendazim induced oxidative stress in male goats.
Daundkar PS1, Rampal S2.
- 1Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India. Electronic address: email@example.com.
- 2Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
In the present investigation, ameliorative effect of selenium on carbendazim induced oral sub chronic toxicity in bucks was assessed by studying various indices of antioxidant defense system.
Bucks were randomly divided into four groups of four animals each.
- Group I served as control,
- Group II was orally drenched carbendazim at the dose rate of 50mg/kg body weight for 90 consecutive days.
- Group III was orally administered selenium in the form of sodium selenite at the dose rate of 0.05mg/kg body weight for 90 consecutive days.
- Group IV was orally administered carbendazim along with selenium at the same dosages as Group II and III.
Prolonged administration of carbendazim produced oxidative stress in goat bucks as evidenced by increase in lipid peroxidation and decline in total antioxidant capacity. The increase in the activity of antioxidant enzymes was not sufficient to prevent pesticide induced oxidative stress.
Selenium supplementation provides some amelioration against this effect. Further study is needed to prove ameliorative potential of this antioxidant against carbendazim induced toxicity in goat bucks.
Copyright © 2014 Elsevier B.V. All rights reserved.
KEYWORDS: Amelioration; Carbendazim; Male goats; Oxidative stress; Selenium
The source of the experiencePubMed
Concepts, symbols and science items
Activities and commonsteps
Reproductive system disease