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Selenium, chemotherapy and heart disease



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I assume the authors mean Doxorubicin  the trade name of which is Adriamycin; pegylated liposomal form trade name Doxil; nonpegylated liposomal form trade name Myocet), also known as hydroxydaunorubicin and hydroxydaunomycin.

It is a drug used in cancer chemotherapy and derived by chemical semisynthesis from a bacterial species. It is an anthracycline antibiotic .

Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted. These symptoms were later found prevalent in a wide belt extending from northeast to southwest China, all due to selenium-deficient soil. The disease peaked in 1960−1970, claiming thousands of lives

A description of the experience

Thromb Haemost. 2014 Oct 30;113(2). [Epub ahead of print]

Selenoproteins and cardiovascular stress.

Rose AH, Hoffmann PR1.  1Peter R. Hoffmann, University of Hawaii, John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, HI 96813, USA, Fax: +1 808 692 1968, E-mail: peterrh@hawaii.edu.

Dietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others.

In this review, we summarise the current understanding of the roles these selenoproteins play in protecting the cardiovascular system from different types of stress including ischaemia-reperfusion, homocysteine dysregulation, myocardial hypertrophy, doxirubicin toxicity, Keshan disease, and others.

KEYWORDS:  Cardiovascular; heart; oxidative stress; selenium; selenoproteins

PMID:  25354851

The source of the experience


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