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Mercaptopurine (also called 6-mercaptopurine, 6-MP or its brand name Purinethol is an immunosuppressive medication. It is used to treat acute lymphocytic leukemia, Crohn's disease, and ulcerative colitis. It is a thiopurine.

Side effects

Some of the adverse reactions of taking mercaptopurine will include diarrhea, nausea, vomiting, loss of appetite, fatigue, stomach/abdominal pain, weakness, skin rash, darkening of the skin, and hair loss. Serious adverse reactions include mouth sores, fever, sore throat, easy bruising or bleeding, pinpoint red spots on the skin, yellowing of eyes or skin, dark urine, and painful or difficult urination. Other more serious side effects include black or tarry stools (melena), bloody stools, and bloody urine.

Symptoms of allergic reaction to mercaptopurine include rash, itching, swelling, dizziness, trouble breathing, and inflammation of the pancreas.

Mercaptopurine causes myelosuppression, suppressing the production of white blood cells and red blood cells. It may be toxic to bone marrow. Weekly blood counts are recommended for patients on mercaptopurine. The patient should stop taking the medication at least temporarily if there is an unexplained, abnormally large drop in white blood cell count, or any other blood count.

Toxicity of mercaptopurine can be linked to genetic polymorphisms in thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA). Patients with specific allele variants will require dose adjustments. Caucasian patients with a variant allele of the ITPA gene, experience higher rates of febrile neuropenia than patients of other ethnic groups, due to differences in allelic frequencies among ethnicities

On Feb, 7, 2016: 1,264 people reported to have side effects when taking Purinethol. Among them, 3 people (0.24%) have Hallucination.

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On Jan, 28, 2016: 1,264 people reported to have side effects when taking Purinethol. Among them, 9 people (0.71%) have Death.

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Top conditions involved for these people  :

1. Crohn's disease (3 people, 33.33%)
2. Colitis ulcerative (2 people, 22.22%)
3. Chronic myeloid leukaemia (1 people, 11.11%)
4. Hyperthyroidism (1 people, 11.11%)