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Potential antineoplastic effects of Aloe-emodin: a comprehensive review



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Neoplasm (from Ancient Greek νέος- neo "new" and πλάσμα plasma "formation, creation") is an abnormal growth of tissue, and when also forming a mass is commonly referred to as a tumor or tumour. This abnormal growth (neoplasia) usually but not always forms a mass

A description of the experience

Am J Chin Med. 2014;42(2):275-88. doi: 10.1142/S0192415X14500189.

Potential antineoplastic effects of Aloe-emodin: a comprehensive review.

Chen R1, Zhang J, Hu Y, Wang S, Chen M, Wang Y.

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.


Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities.

With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells involving multi-channel mechanisms, including the disruption of cell cycle, induction of apoptosis, anti-metastasis, antiangiogenic, and strengthening of immune function.

Experimental data have revealed AE as a potentially potent anti-cancer candidate.

Despite this, the pharmaceutical application of AE is still in a fledging period as most research has concentrated on the elucidation of the molecular mechanism of action of existing treatments, rather than the development of novel formulations. Therefore, the present review summarizes the potential toxicity, molecular mechanism, pharmacokinetic characteristics, and pharmaceutical development of AE as an antineoplastic agent.

This is based on its physicochemical properties, in an attempt to encourage further research on AE as a potential anti-cancer agent.

PMID: 24707862

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