Nucynta and Nucynta er
Type of Spiritual Experience
A description of the experience
Tapentadol (brand names: Nucynta, Palexia and Tapal) is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.
It is similar to tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine. Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites. Tapentadol is not a pro-drug and therefore does not rely on metabolism to produce its therapeutic effects; this makes it a useful moderate-potency analgesic option for patients who do not respond adequately to more commonly used opioids due to genetic disposition (poor metabolizers of CYP3A4 and CYP2D6), as well as providing a more consistent dosage-response range among the patient population.
Tapentadol general potency is somewhere between that of tramadol and morphine, with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects. It is generally regarded as a weak-moderate strength opioid.
Most common Nucynta side effects from eHealthme
- Drug ineffective - (404 reports)
- Nausea - (249 reports)
- Pain - (231 reports)
- Dizziness - (181 reports)
- Headache - (169 reports)
- Feeling abnormal - (166 reports)
- Drowsiness - (156 reports)
- Fatigue - (151 reports)
- Confusional state - (148 reports)
- Depression - (148 reports)
On Jan, 25, 2017 3,693 people reported to have side effects when taking Nucynta.
Among them, 97 people (2.63%) have Death
On Jan, 26, 2017 3,693 people reported to have side effects when taking Nucynta. Among them, 139 people (3.76%) have Hallucination
On Jan, 29, 2017 3,693 people reported to have side effects when taking Nucynta. Among them, 24 people (0.65%) have Hallucination, Auditory
Most common Nucynta er side effects
- Drug ineffective - (190 reports)
- Drowsiness - (69 reports)
- Pain - (66 reports)
- Nausea - (53 reports)
- Headache - (53 reports)
- Serotonin syndrome - (50 reports)
- Feeling abnormal - (48 reports)
- Dizziness - (44 reports)
- High blood pressure - (42 reports)
- Withdrawal syndrome - (41 reports)