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Orphenadrine   - sold under the brand names: Norflex , Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan and others;  is used to treat painful muscle spasms,  as well as the treatment of some aspects of Parkinson's Disease. It is often used against pain and muscle spasm such as lumbago and sciatica. Orphenadrine is also used to treat muscle injuries, skeletal muscle tension, rigidity secondary to afflictions such as prolapsed discs, and degenerative soft tissue disease especially in the lower back, neck, and joints. The orphenadrine salt used for Parkinsonism is the hydrochloride, whereas the muscle relaxant tablet are the citrate. The manufacturers' descriptions of orphenadrine indicate that the salts are not interchangeable; one reason may be that the citrate can be irritating when injected.  Common side effects include: dry mouth, dizziness, drowsiness, restlessness, insomnia, constipation, urine retention, and orthostatic hypotension.  Euphoria is an effect reported by many patients and “orphenadrine has been investigated for use against depression, as first reported in June 1958 in the American Journal of Psychiatry”

Orphenadrine is known to have the following pharmacology:

• mACh receptor antagonist (anticholinergic)
• H1 receptor antagonist (antihistamine)
• NMDA receptor antagonist
• NET blocker (norepinephrine reuptake inhibitor)
• Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker
• HERG potassium channel blocker

It is also used to “ potentiate the action of opioid analgesics against moderate to severe neuropathic pain”.  It is as a consequence used ‘recreationally’, though not with a great deal of success

On Jun, 13, 2015: 796 people reported to have side effects when taking Norflex. Among them, 18 people (2.26%) have Hallucination.

On May, 28, 2015: 796 people reported to have side effects when taking Norflex. Among them, 3 people (0.38%) have Death.