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Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (previously known as pregnancy-induced hypertension (PIH)).

Methyldopa is capable of inducing a number of adverse side effects, which range from mild to severe. Nevertheless, they are generally mild when the dose is less than 1 gram per day.[2] Side effects may include:

• Psychological
• Depression and/or even suicidal ideation, as well as nightmares
• Apathy and/or anhedonia, as well as dysphoria
• Anxiety, especially of the social anxiety variant
• Decreased alertness, awareness, and wakefulness
• Impaired attention, focus, and concentration
• Decreased desire, drive, and motivation
• Fatigue or lethargy and/or malaise or lassitude
• Sedation or drowsiness and/or somnolence or sleepiness
• Agitation or restlessness
• Cognitive and memory impairment
• Derealization and/or depersonalization, as well as mild psychosis
• Sexual dysfunction including impaired libido, desire, and drive

Physiological

• Dizziness, lightheadedness, or vertigo
• Miosis or pupil constriction
• Xerostomia or dry mouth
• Gastrointestinal disturbances such as diarrhea and/or constipation
• Headache or migraine
• Myalgia or muscle aches, arthralgia or joint pain, and/or paresthesia ("pins and needles")
• Restless legs syndrome (RLS)
• Parkinsonian symptoms such as muscle tremors, rigidity, hypokinesia, and/or balance or postural instability
• Akathisia, ataxia, dyskinesia as well as even tardive dyskinesia, and/or dystonia
• Bell's palsy or facial paralysis
• Sexual dysfunction consisting of impaired erectile dysfunction and/or anorgasmia
• Hyperprolactinemia or excess prolactin, gynecomastia/breast enlargement in males, and/or amenorrhoea or absence of menstrual cycles in females
• Bradycardia or decreased heart rate
• Hypotension or decreased blood pressure (though this may also be considered a therapeutic benefit)
• Orthostatic hypotension (also known as postural hypotension)
• Hepatitis, hepatotoxicity, or liver dysfunction or damage
• Pancreatitis or inflammation of the pancreas
• Haemolytic anaemia or deficiency in red blood cells (RBCs)
• Myelotoxicity or bone marrow suppression, potentially leading to thrombocytopenia or blood platelet deficiency and/or leukopenia or white blood cell (WBC) deficiency
• Hypersensitivity such as lupus erythematosus, myocarditis, and/or pericarditis
• Lichenoid reactions such as skin lesions and/or rashes
• Pallor

On Sep, 13, 2015: 1,893 people reported to have side effects when taking Methyldopa. Among them, 19 people (1.00%) have Hallucination.

On Sep, 28, 2015: 1,894 people reported to have side effects when taking Methyldopa. Among them, 19 people (1.00%) have Death.

Time on Methyldopa when people have Death  :

On Sep, 13, 2015: 1,637 people reported to have side effects when taking Aldomet. Among them, 20 people (1.22%) have Hallucination.

Time on Aldomet when people have Hallucination  :

On Sep, 29, 2015: 1,637 people reported to have side effects when taking Aldomet. Among them, 26 people (1.59%) have Death.