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Methylergometrine (other names include methylergonovine, methylergobasin, methergine, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. It is a member of the ergoline family and chemically similar to LSD, ergine, ergometrine, and lysergic acid.  According to Jonathan Ott, methylergonovine has LSD-like actions above 2 milligrams. Clinical dosages are ten times lower.

Methylergometrine maleate is marketed under the trade name Methergine.

It is used in obstetrics.  Methylergometrine is a smooth muscle constrictor that mostly acts on the uterus. It is most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion, and also to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth.

Methylergometrine is sometimes used for both prevention [sic] and acute treatment of migraine.

Side effects

Adverse effects include

• Cholinergic effects such as nausea, vomiting, and diarrhea
• Dizziness
• Pulmonary hypertension
• Coronary artery vasoconstriction
• Severe systemic hypertension (especially in patients with preeclampsia)
• Convulsions

In excessive doses, methylergometrine can also lead to cramping, respiratory depression and coma.

On Dec, 14, 2015: 796 people reported to have side effects when taking Methergine. Among them, 9 people (1.13%) have Hallucination.

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On Dec, 20, 2015: 796 people reported to have side effects when taking Methergine. Among them, 17 people (2.14%) have Death.

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