Observations placeholder

Pyridostigmine  trade name Mestinin is a parasympathomimetic and a reversible cholinesterase inhibitor.  

Pyridostigmine is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome.

Pyridostigmine sometimes is used to treat orthostatic hypotension [dizzy spells]. It has also been used in chronic axonal polyneuropathy.

It is also being prescribed 'off-label' for the postural tachycardia syndrome as well as complications resulting from Ehlers-Danlos Syndrome

Side effects

Common side effects include

• Sweating
• Diarrhea
• Nausea
• Vomiting
• Abdominal cramps
• Increased salivation
• Tearing
• Increased bronchial secretions
• Constricted pupils
• Facial flushing due to vasodilation
• Erectile dysfunction

On Dec, 9, 2015: 1,337 people reported to have side effects when taking Mestinon. Among them, 13 people (0.97%) have Death.

Time on Mestinon when people have Death  :

Gender of people who have Death when taking Mestinon  :

Age of people who have Death when taking Mestinon  :

Top conditions involved for these people  :

1. Myasthenia gravis (3 people, 23.08%)
2. Amyotrophic lateral sclerosis (2 people, 15.38%)
3. Osteoporosis (1 people, 7.69%)
4. Muscular weakness (1 people, 7.69%)
5. Dementia alzheimer's type (1 people, 7.69%)