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Chlordiazepoxid, is a sedative/hypnotic drug and benzodiazepine.

Chlordiazepoxide was the first benzodiazepine to be synthesized and the discovery of chlordiazepoxide was by pure chance Chlordiazepoxide and other benzodiazepines were initially accepted with widespread public approval but were followed with widespread public disapproval and recommendations for more restrictive medical guidelines for its use

Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life. The drug has amnestic, anticonvulsant, anxiolytic, hypnotic and skeletal muscle relaxant properties.

Side-effects

Common side-effects of chlordiazepoxide include:

• Confusion
• Constipation
• Drowsiness
• Fainting
• Altered sex drive
• Liver problems
• Lack of muscle coordination
• Minor menstrual irregularities
• Nausea
• Skin rash or eruptions
• Swelling due to fluid retention
• Yellow eyes and skin

Chlordiazepoxide in laboratory mice studies impairs latent learning. Benzodiazepines impair learning and memory via their action on benzodiazepine receptors, which causes a dysfunction in the cholinergic neuronal system in mice It was later found that scopolamine impairment in learning was caused by an increase in benzodiazapine/GABA activity (and that benzodiapines were not associated with the cholinergic system) In tests of various benzodiazepine compounds, chlordiazepoxide was found to cause the most profound reduction in the turnover of 5HT (serotonin) in rats. Serotonin is closely involved in regulating mood and may be one of the causes of feelings of depression in rats using chlordiazepoxide or other benzodiazepines

On Jan, 2, 2016: 255 people reported to have side effects when taking Limbitrol. Among them, 9 people (3.53%) have Hallucination.

On Jan, 2, 2016: 255 people reported to have side effects when taking Limbitrol. Among them, 3 people (1.18%) have Death.